Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Somdet Phra Sungharaj Nyanasumvara Geriatric Hospital, Department of Medical Services, Ministry of Public health, Chon Buri Province, Thailand.
Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Ageing Res Rev. 2022 Aug;79:101639. doi: 10.1016/j.arr.2022.101639. Epub 2022 May 7.
This study aims to systematically review and meta-analyze the nitro-oxidative stress (O&NS)/antioxidant (ANTIOX) ratio in the peripheral blood of people with mild cognitive impairment (MCI). We searched PubMed, Scopus, Google Scholar, and Web of Science for articles published from inception until July 31, 2021. Forty-six studies on 3.798 MCI individuals and 6.063 healthy controls were included. The O&NS/ANTIOX ratio was significantly higher in MCI than in controls with a Standardized Mean Difference (SMD)= 0.378 (95% CI: 0.250; 0.506). MCI individuals showed increased lipid peroxidation (SMD=0.774, 95%CI: 4.416; 1.132) and O&NS-associated toxicity (SMD=0.621, CI: 0.377; 0.865) and reduced glutathione (GSH) defenses (SMD=0.725, 95%CI: 0.269; 1.182) as compared with controls. MCI was also accompanied by significantly increased homocysteine (SMD=0.320, CI: 0.059; 0.581), but not protein oxidation, and lowered non-vitamin (SMD=0.347, CI: 0.168; 0.527) and vitamin (SMD=0.564, CI: 0.129; 0.999) antioxidant defenses. The results show that MCI is at least in part due to increased neuro-oxidative toxicity and suggest that treatments targeting lipid peroxidation and the GSH system may be used to treat or prevent MCI.
本研究旨在系统地回顾和荟萃分析轻度认知障碍（MCI）患者外周血中的硝基-氧化应激（O&NS）/抗氧化（ANTIOX）比值。我们检索了 PubMed、Scopus、Google Scholar 和 Web of Science 中从建库到 2021 年 7 月 31 日发表的文章。共纳入 46 项关于 3798 名 MCI 个体和 6063 名健康对照的研究。MCI 患者的 O&NS/ANTIOX 比值明显高于对照组，标准化均数差（SMD）为 0.378（95%CI：0.250；0.506）。与对照组相比，MCI 个体表现出脂质过氧化（SMD=0.774，95%CI：4.416；1.132）和 O&NS 相关毒性（SMD=0.621，CI：0.377；0.865）增加以及谷胱甘肽（GSH）防御（SMD=0.725，95%CI：0.269；1.182）减少。与对照组相比，MCI 还伴有同型半胱氨酸（SMD=0.320，CI：0.059；0.581）显著升高，但蛋白氧化无显著升高，而非维生素（SMD=0.347，CI：0.168；0.527）和维生素（SMD=0.564，CI：0.129；0.999）抗氧化防御降低。结果表明，MCI 至少部分是由于神经氧化毒性增加所致，提示针对脂质过氧化和 GSH 系统的治疗可能用于治疗或预防 MCI。
