Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Department of Radiation Oncology, Penn State Cancer Institute, Hershey, Pennsylvania, USA.
Cancer Rep (Hoboken). 2022 Sep;5(9):e1621. doi: 10.1002/cnr2.1621. Epub 2022 May 10.
Primary laryngeal chondrosarcomas are rare entities whose excellent survival rates following resection promote conservative surgical approaches to maintain quality of life without compromising outcomes. There are excellent outcomes in skull base chondrosarcomas treated with maximal safe resection and post-operative proton therapy. Extrapolating from these findings, we report our institutional experience treating symptomatic or growing laryngeal chondrosarcomas using proton beam therapy.
Demographic information, clinical characteristics, treatment details, and follow-up data were collected and summarized. Patients were monitored with serial imaging and examination. Stable disease was defined as no progression of disease on imaging. Two patients underwent subtotal resections followed by post-operative radiotherapy, while two patients received definitive radiotherapy. All patients are currently alive with stable disease at their last follow-up.
This case series provides initial evidence for excellent outcomes with maximal safe surgical resection followed by proton beam therapy for patients with symptomatic or growing laryngeal chondrosarcomas. Larger studies are warranted to determine the optimal therapeutic approach.
原发性喉软骨肉瘤较为罕见，其切除后的极佳存活率促使人们采取保守的手术方法，在不影响疗效的前提下维持生活质量。颅底软骨肉瘤通过最大限度安全切除和术后质子治疗可获得极佳的效果。基于这些发现，我们报告了本机构使用质子束疗法治疗有症状或生长的喉软骨肉瘤的经验。
收集并总结了人口统计学信息、临床特征、治疗细节和随访数据。通过连续影像学和检查对患者进行监测。疾病稳定定义为影像学上无疾病进展。两名患者接受了次全切除，随后进行了术后放疗，而两名患者则接受了根治性放疗。所有患者目前仍存活，最后一次随访时疾病稳定。
本病例系列提供了初步证据，表明对于有症状或生长的喉软骨肉瘤患者，最大限度安全手术切除后行质子束治疗可获得极佳的效果。需要更大规模的研究来确定最佳的治疗方法。
