严重急性呼吸综合征冠状病毒2型奥密克戎变异株病毒分离株对干扰素治疗高度敏感。 - Suppr

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超能文献

SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment.

作者信息

Bojkova Denisa, Rothenburger Tamara, Ciesek Sandra, Wass Mark N, Michaelis Martin, Cinatl Jindrich

机构信息

Institute for Medical Virology, University Hospital, Goethe University, Frankfurt am Main, Germany.

German Center for Infection Research, DZIF, External partner site, Frankfurt am Main, Germany.

出版信息

Cell Discov. 2022 May 10;8(1):42. doi: 10.1038/s41421-022-00408-z.

DOI:10.1038/s41421-022-00408-z

PMID:35538050

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9087166/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73dd/9090759/c8bb261a1bd4/41421_2022_408_Fig1_HTML.jpg

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Outcomes of laboratory-confirmed SARS-CoV-2 infection in the Omicron-driven fourth wave compared with previous waves in the Western Cape Province, South Africa.在南非西开普省，与之前的几波疫情相比，奥密克戎驱动的第四波疫情中实验室确诊的 SARS-CoV-2 感染的结果。

Trop Med Int Health. 2022 Jun;27(6):564-573. doi: 10.1111/tmi.13752. Epub 2022 May 10.

Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates.与严重急性呼吸综合征冠状病毒2（SARS-CoV-2）德尔塔变异株相比，奥密克戎变异株的干扰素拮抗作用降低，但药物敏感性相似。

Cell Res. 2022 Mar;32(3):319-321. doi: 10.1038/s41422-022-00619-9. Epub 2022 Jan 21.

Omicron's feeble attack on the lungs could make it less dangerous.奥密克戎对肺部的攻击较弱，这可能使其危险性降低。

Nature. 2022 Jan;601(7892):177. doi: 10.1038/d41586-022-00007-8.

Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses - are we our own worst enemy?由 SARS-CoV-2 及相关冠状病毒引起的免疫失调和免疫病理 - 我们是否是我们自己最大的敌人？

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