Department of Psychiatry, Arak University of Medical Sciences, Arak, Iran.
Curr Mol Pharmacol. 2023;16(3):307-320. doi: 10.2174/1874467215666220509213122.
Effective and better-tolerated agents for the treatment of most of psychiatric disorders are one of the main challenges. Recently, anti-inflammatory, antioxidants and neuroprotective agents as adjuvant therapy have been shown to be able to play a role against the degenerative mechanisms commonly related to psychiatric conditions. Berberine, a biologically active alkaloid derived from various plants, represents many pharmacological impacts, such as antimicrobial, antidiabetic, anticancer, antioxidant and anti-inflammatory activities. This compound also protects neurons and improves the survival, growth and action of nerve cells due to its high potential for crossing the blood-brain barrier. Ample evidence reported that berberine had been associated with CNS-related disorders, including Alzheimer's, cerebral ischemia, mental depression, schizophrenia and anxiety. Thus, in this review, we aimed to indicate the effectiveness of berberine on mental disorders.
有效且耐受性更好的治疗大多数精神疾病的药物是主要挑战之一。最近，抗炎、抗氧化和神经保护剂作为辅助治疗已被证明能够对抗与精神疾病相关的常见退行性机制。小檗碱是一种从各种植物中提取的生物活性生物碱，具有多种药理作用，如抗菌、抗糖尿病、抗癌、抗氧化和抗炎作用。由于其具有很高的穿透血脑屏障的潜力，该化合物还可以保护神经元并提高神经元的存活、生长和功能。大量证据表明，小檗碱与与中枢神经系统相关的疾病有关，包括阿尔茨海默病、脑缺血、精神抑郁、精神分裂症和焦虑症。因此，在这篇综述中，我们旨在指出小檗碱对精神疾病的有效性。
