一种由色酮和异吲哚酮简便合成3-水杨酰基喹啉-4-羧酸酯的方法。
A simple and convenient synthesis of 3-salicyloylquinoline-4-carboxylic esters from chromone and isatin.
作者信息
Wang Xuequan, Yang Zhixin, Miu Weihang, Ye Pingting, Bai Mengjiao, Duan Suyue, Shen Xianfu
机构信息
Key Laboratory of Natural Pharmaceutical and Chemical Biology of Yunnan Province, School of Science, Honghe University Mengzi Yunnan 661100 China
Center for Yunnan-Guizhou Plateau Chemical Functional Materials and Pollution Control, Qujing Normal University 655011 P. R. China.
出版信息
RSC Adv. 2019 Nov 12;9(63):37057-37060. doi: 10.1039/c9ra08124k. eCollection 2019 Nov 11.
A simple and convenient synthesis of 3-salicyloylquinoline-4-carboxylic esters has been developed through an AlCl-catalyzed reaction of easily available Baylis-Hillman adducts from chromones and isatin-derivatives. This reaction involves esterification, cyclization and ring opening in a one-step process, and provides an efficient approach for easy access to a series of valuable salicyloylquinoline derivatives with high yields. Moreover, this protocol offers several advantages, such as availability of starting materials, economic availability, operational simplicity and mild reaction conditions.
通过AlCl催化的、由色酮和异靛蓝衍生物制备的易于获得的Baylis-Hillman加合物的反应，开发了一种简单便捷的3-水杨酰基喹啉-4-羧酸酯的合成方法。该反应在一步过程中涉及酯化、环化和开环，并提供了一种高效的方法，能够以高收率轻松获得一系列有价值的水杨酰基喹啉衍生物。此外，该方法具有几个优点，如起始原料易得、经济可行、操作简单和反应条件温和。
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