Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Żeromskiego 116, 90-924 Łódź, Poland.
Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Żeromskiego 116, 90-924 Łódź, Poland.
Molecules. 2022 Oct 11;27(20):6809. doi: 10.3390/molecules27206809.
Herein, we describe the synthesis of a variety of chiral hybrid pyrrolidine-chromanone polycyclic derivatives. A convenient (3+2)-annulation of azomethine ylides with chromone-3-carboxylic acid realized under Brønsted base catalysis produced highly functionalized products in high yields with good stereoselectivities through asymmetric, intermolecular, and decarboxylative (3+2)-cyclization.
本文描述了多种手性杂吡咯烷-色满酮多环衍生物的合成。在布朗斯特碱催化下，亚胺叶立德与色酮-3-羧酸的方便（3+2）-环加成反应，通过不对称、分子间和脱羧（3+2）-环化反应，以高产率和良好的立体选择性得到了高度官能化的产物。
