用于磁共振成像的线性聚乙烯醇-二乙三胺五乙酸-钆共轭物
Linear PVA-DTPA-Gd conjugate for magnetic resonance imaging.
作者信息
Xu Weibing, Lin Zhiyan, Li Guichen, Long Haitao, Du Mingyuan, Fu Guorui, Pu Lumei
机构信息
College of Science, Gansu Agricultural University Lanzhou 730000 Gansu Province P. R. China
Clinical Medical College, Gansu University of Chinese Medicine Lanzhou 730000 China
出版信息
RSC Adv. 2019 Nov 12;9(63):37052-37056. doi: 10.1039/c9ra05607f. eCollection 2019 Nov 11.
In this study, we report the preparation and characterization of the PVA-DTPA-Gd conjugate as a potential MRI contrast agent (CA). The value and the / ratio were about 5.6 mM s and 1.31, respectively. toxicity studies not only demonstrated that the polymeric system possessed good biocompatibility, but also proved that the conjugate could be an attractive candidate for CA.
在本研究中，我们报道了聚乙烯醇-二乙三胺五乙酸-钆（PVA-DTPA-Gd）共轭物作为一种潜在的磁共振成像造影剂（CA）的制备及表征。其弛豫率值和纵向弛豫率与横向弛豫率之比分别约为5.6 mM⁻¹s⁻¹和1.31。毒性研究不仅表明该聚合物体系具有良好的生物相容性，还证明该共轭物可能是一种有吸引力的造影剂候选物。
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