来自……果实的抗乙酰胆碱酯酶三萜类化合物 。 你提供的原文不完整，句末缺少具体信息。
Antiacetylcholinesterase triterpenes from the fruits of .
作者信息
Nian Yin, Lu Ni-Hong, Liu Xiao-Ling, Li Da-Shan, Zhou Lin, Qiu Ming-Hua
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences Kunming 650201 People's Republic of China
Department of Respiratory Medicine, The Third People's Hospital of Kunming Kunming 650041 People's Republic of China.
出版信息
RSC Adv. 2018 Feb 19;8(14):7832-7838. doi: 10.1039/c8ra00291f. eCollection 2018 Feb 14.
Two new cycloartane triterpenes, cimyunnin E (1), containing a unique oxaspiro[4.4]nonanedione moiety based on rings D and E, together with cimicifine B (2), a 25,26,27-trinortriterpene featuring a pyridine ring E, were purified from the fruits of . Their structures were elucidated by spectroscopic methods and ECD (electronic circular dichroism calculations). Compounds 1 and 2 showed significant acetylcholinesterase (AChE) inhibition with IC values of 1.58 and 3.87 μM, respectively. In addition, they noticeably enhanced the neurite outgrowth of nerve growth factor (NGF) mediated PC12 cells at a concentration of 10 μM.
从……果实中纯化得到了两种新的环阿尔廷烷三萜，含有基于D环和E环的独特氧杂螺[4.4]壬二酮部分的升麻宁E（1），以及具有吡啶E环的25,26,27-三降三萜升麻碱B（2）。通过光谱方法和ECD（电子圆二色性计算）阐明了它们的结构。化合物1和2对乙酰胆碱酯酶（AChE）具有显著抑制作用，IC值分别为1.58和3.87 μM。此外，它们在浓度为10 μM时显著促进了神经生长因子（NGF）介导的PC12细胞的神经突生长。
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