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丙酮酸乙酯减轻大鼠蛛网膜下腔出血后迟发性实验性脑血管痉挛：JNK信号通路的潜在作用

Ethyl pyruvate attenuates delayed experimental cerebral vasospasm following subarachnoid haemorrhage in rats: possible role of JNK pathway.

作者信息

Jin Ke, Wu Hui, Lv Tao, Dai Jiong, Zhang Xiaohua, Jin Yichao

机构信息

Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University, School of Medicine 160, Pujian Road Shanghai 200127 People's Republic of China

出版信息

RSC Adv. 2018 Feb 16;8(14):7726-7734. doi: 10.1039/c7ra10801j. eCollection 2018 Feb 14.

DOI:10.1039/c7ra10801j
PMID:35539121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9078488/
Abstract

The pathophysiology of delayed cerebral vasospasm (CVS) after subarachnoid haemorrhage (SAH) is multifaceted and involves endothelial apoptosis and inflammation. Ethyl pyruvate (EP) could attenuate early brain injury following SAH anti-inflammation and inhibition of the c-Jun N-terminal kinase (JNK) signalling pathway. However, the role of EP in the delayed CVS has yet to be determined. In this study, we examined the effect of EP on endothelial apoptosis and inflammation and explore possible signalling pathways. We found that EP could significantly attenuate the delayed CVS. Possible mechanisms include a decrease in the endothelial cell apoptosis of the basilar artery and alleviation of endothelial inflammation. The JNK signalling pathway may play an important role in the neuroprotective effects of EP on delayed CVS. The results suggest that EP may be a possible therapy for delayed CVS, and the JNK signalling pathway should be targeted for therapeutic purposes in the future.

摘要

蛛网膜下腔出血（SAH）后迟发性脑血管痉挛（CVS）的病理生理学是多方面的，涉及内皮细胞凋亡和炎症。丙酮酸乙酯（EP）可减轻SAH后的早期脑损伤，具有抗炎作用并抑制c-Jun氨基末端激酶（JNK）信号通路。然而，EP在迟发性CVS中的作用尚未确定。在本研究中，我们研究了EP对内皮细胞凋亡和炎症的影响，并探索了可能的信号通路。我们发现EP可显著减轻迟发性CVS。可能的机制包括基底动脉内皮细胞凋亡减少和内皮炎症减轻。JNK信号通路可能在EP对迟发性CVS的神经保护作用中发挥重要作用。结果表明，EP可能是治疗迟发性CVS的一种可能疗法，未来应针对JNK信号通路进行治疗。

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本文引用的文献

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Effect of delayed onset prostacyclin on markers of endothelial function and damage after subarachnoid hemorrhage.延迟起效前列环素对蛛网膜下腔出血后内皮功能及损伤标志物的影响。
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Ethyl Pyruvate Attenuates Early Brain Injury Following Subarachnoid Hemorrhage in the Endovascular Perforation Rabbit Model Possibly Via Anti-inflammation and Inhibition of JNK Signaling Pathway.
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