Dluzen D E, Ramirez V D
Neuroendocrinology. 1987 Apr;45(4):328-32. doi: 10.1159/000124748.
In the present article we report that in vivo LHRH output as measured at the anterior pituitary following castration significantly increased, due to larger and more frequent LHRH signals arriving to this gland. This contrasts with the decreased amplitude and overall mean LHRH release of castrate males bearing a push-pull cannula within the hypothalamus. These divergent results have generated a new thesis regarding the role of gonadal steroids upon the LHRH pulse generator. This thesis submits that following castration there is an increased frequency and decreased amplitude of the LHRH signal from discrete loci within the medial basal hypothalamus, but an increased synchrony of LHRH release throughout the entire hypothalamus, resulting in an increased frequency and amplitude of LHRH arriving at the anterior pituitary.
在本文中，我们报告称，去势后在前脑垂体测量的体内促性腺激素释放激素（LHRH）输出显著增加，这是因为到达该腺体的LHRH信号更大且更频繁。这与在下丘脑内植入推挽式套管的去势雄性动物LHRH释放幅度降低和总体平均释放量减少形成对比。这些不同的结果产生了一个关于性腺类固醇对LHRH脉冲发生器作用的新论点。该论点认为，去势后，来自内侧基底下丘脑离散位点的LHRH信号频率增加而幅度降低，但整个下丘脑LHRH释放的同步性增加，导致到达前脑垂体的LHRH频率和幅度增加。
