Liu Jun, Liu Siqian, Li Yaling, Xue Jiayan, He Youyi, Liu Fuchi, Yang Li, Hu Junhui, Xiong Zhengye, Long Lizhen
College of Physics Science and Technology & Guangxi Key Laboratory of Nuclear Physics and Technology, Guangxi Normal University Guilin 541004 P. R. China
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guilin 541004 P. R. China.
RSC Adv. 2019 Dec 10;9(70):40835-40844. doi: 10.1039/c9ra08116j. eCollection 2019 Dec 9.
To research and develop potential multifunctional nanoprobes for biological application, lanthanide-doped MCM-41 (Ln-MCM-41, Ln = Gd/Eu) silica nanoparticles with excellent pore structure and optical-magnetic properties were synthesized a facile and economical sol-gel method. The microstructure and pore distribution of Ln-MCM-41 nanoparticles were obviously affected by the Ln-doping. As the Ln/Si mole ratio increased, the specific surface area and total pore volume of Ln-MCM-41 nanoparticles rapidly decreased. However, the Ln-MCM-41 nanoparticles still retained the typical well-ordered mesoporous structure, and exhibited excellent drug release behavior. Moreover, the drug release rate of Ln-MCM-41 was remarkably pH-dependent and increased gradually upon decreasing pH. Additionally, these nanoparticles also exhibit considerable photoluminescence properties, living cells photoluminescence imaging , and paramagnetism behavior at room temperature due to the Ln-ions doping. Our research shows the possibility of our Ln-MCM-41 nanoparticles as multifunctional nanoprobes for application in bioseparation, bioimaging, and drug delivery.
为了研发具有生物应用潜力的多功能纳米探针，采用简便经济的溶胶-凝胶法合成了具有优异孔结构和光磁性能的镧系掺杂MCM-41（Ln-MCM-41，Ln = Gd/Eu）二氧化硅纳米颗粒。Ln-MCM-41纳米颗粒的微观结构和孔分布明显受Ln掺杂的影响。随着Ln/Si摩尔比的增加，Ln-MCM-41纳米颗粒的比表面积和总孔体积迅速减小。然而，Ln-MCM-41纳米颗粒仍保留典型的有序介孔结构，并表现出优异的药物释放行为。此外，Ln-MCM-41的药物释放速率显著依赖于pH值，且随着pH值降低而逐渐增加。另外，由于Ln离子掺杂，这些纳米颗粒在室温下还表现出可观的光致发光性能、活细胞光致发光成像以及顺磁性行为。我们的研究表明，我们的Ln-MCM-41纳米颗粒作为多功能纳米探针应用于生物分离、生物成像和药物递送具有可能性。
