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一种新型平面正方形铂（II）配合物，作为单体和二聚体G-四链体DNA结合剂。

A novel square-planar Pt(ii) complex as a monomeric and dimeric G-quadruplex DNA binder.

作者信息

Zhou Chun-Qiong, Li Zi-Qi, Liao Ting-Cong, Ma Tian-Zhu, Chen Shuo-Bin, Liang Yuan-Yuan

机构信息

Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University Guangzhou 510515 China

School of Pharmaceutical Sciences, Sun Yat-sen University Guangzhou 51006 China.

出版信息

RSC Adv. 2018 Jun 26;8(41):23257-23261. doi: 10.1039/c8ra03606c. eCollection 2018 Jun 21.

DOI:10.1039/c8ra03606c
PMID:35540167
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9081585/
Abstract

A novel phenanthroimidazole ethylenediamine Pt(ii) complex with coumarin derivative (1) was synthesized and showed higher affinity, selectivity and thermal stabilization for mixed-type dimeric G-quadruplexes (G2T1) over monomeric G-quadruplexes (G1) and duplex DNA. Complex 1 could bind to G-quadruplexes end-stacking and external-binding modes.

摘要

合成了一种带有香豆素衍生物的新型菲并咪唑乙二胺铂（II）配合物（1），与单体G-四链体（G1）和双链DNA相比，其对混合型二聚体G-四链体（G2T1）表现出更高的亲和力、选择性和热稳定性。配合物1可以通过末端堆积和外部结合模式与G-四链体结合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/9081585/dba60b6a7e05/c8ra03606c-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/9081585/82ed754be86d/c8ra03606c-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/9081585/54b661d3fdf4/c8ra03606c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/9081585/0504d5014abe/c8ra03606c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/9081585/8e905d537433/c8ra03606c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/9081585/b172298cb839/c8ra03606c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/9081585/dba60b6a7e05/c8ra03606c-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/9081585/82ed754be86d/c8ra03606c-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/9081585/54b661d3fdf4/c8ra03606c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/9081585/0504d5014abe/c8ra03606c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/9081585/8e905d537433/c8ra03606c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/9081585/b172298cb839/c8ra03606c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1353/9081585/dba60b6a7e05/c8ra03606c-f5.jpg

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本文引用的文献

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On the origins of the conflict between Rosalind Franklin and Maurice Wilkins.关于罗莎琳德·富兰克林与莫里斯·威尔金斯之间冲突的起源。
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Specifically targeting mixed-type dimeric G-quadruplexes using berberine dimers.使用小檗碱二聚体特异性靶向混合型二聚体G-四链体。
Org Biomol Chem. 2017 Dec 13;15(48):10221-10229. doi: 10.1039/c7ob02326j.
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Adaptive and Specific Recognition of Telomeric G-Quadruplexes via Polyvalency Induced Unstacking of Binding Units.通过多价诱导结合单元解堆叠实现端粒 G-四链体的适应性和特异性识别。
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Dinickel-Salphen Complexes as Binders of Human Telomeric Dimeric G-Quadruplexes.二镍-双酚配合物作为人端粒二聚体G-四链体的结合剂
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Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole.一种新型三芳基取代咪唑对端粒多聚体G-四链体的特异性靶向作用
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C9orf72 is required for proper macrophage and microglial function in mice.C9orf72对于小鼠体内巨噬细胞和小胶质细胞的正常功能是必需的。
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Quadruplex Nucleic Acids as Novel Therapeutic Targets.四链核酸作为新型治疗靶点
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The exception that confirms the rule: a higher-order telomeric G-quadruplex structure more stable in sodium than in potassium.通则中的例外情况：一种高阶端粒G-四链体结构在钠中比在钾中更稳定。
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Highly selective, sensitive and fluorescent sensing of dimeric G-quadruplexes by a dimeric berberine.一种二聚体小檗碱对二聚体G-四链体的高选择性、高灵敏度荧光传感
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