一种新型平面正方形铂（II）配合物，作为单体和二聚体G-四链体DNA结合剂。
A novel square-planar Pt(ii) complex as a monomeric and dimeric G-quadruplex DNA binder.
作者信息
Zhou Chun-Qiong, Li Zi-Qi, Liao Ting-Cong, Ma Tian-Zhu, Chen Shuo-Bin, Liang Yuan-Yuan
机构信息
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University Guangzhou 510515 China
School of Pharmaceutical Sciences, Sun Yat-sen University Guangzhou 51006 China.
出版信息
RSC Adv. 2018 Jun 26;8(41):23257-23261. doi: 10.1039/c8ra03606c. eCollection 2018 Jun 21.
A novel phenanthroimidazole ethylenediamine Pt(ii) complex with coumarin derivative (1) was synthesized and showed higher affinity, selectivity and thermal stabilization for mixed-type dimeric G-quadruplexes (G2T1) over monomeric G-quadruplexes (G1) and duplex DNA. Complex 1 could bind to G-quadruplexes end-stacking and external-binding modes.
合成了一种带有香豆素衍生物的新型菲并咪唑乙二胺铂（II）配合物（1），与单体G-四链体（G1）和双链DNA相比，其对混合型二聚体G-四链体（G2T1）表现出更高的亲和力、选择性和热稳定性。配合物1可以通过末端堆积和外部结合模式与G-四链体结合。
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