Zuckier L S, Axelrod M S, Wexler J P, Heller S L, Blaufox M D
Nucl Med Commun. 1987 Jan;8(1):49-61. doi: 10.1097/00006231-198701000-00008.
Several patients with renal failure in whom the kidneys were more clearly imaged with 99Tcm-DTPA than 131I-Hippuran were recently observed. We have postulated that our newer generation gamma-cameras have a reduced capacity to image 131I in comparison to older generation cameras. This hypothesis was tested by comparing representative older and newer imaging systems. Full-width tenth-maximum 99Tcm linespread functions were 1.20 and 1.55 cm for the older and newer cameras, respectively. The 99Tcm count rate on the newer camera was 111% that of the older camera, and the observed kidney to background count ratios in a phantom model were virtually identical for the two cameras imaging a number of simulated 99Tcm count distributions. Full-width tenth-maximum 131I linespreads were 1.55 and 4.78 cm, respectively, on the older and newer cameras and the 131I count rate on the newer camera was 27% of the count rate on the older system. The phantom model demonstrated a consistently lower 131I perceived kidney to background count ratio on the newer gamma-camera compared to the older system. These findings should be considered in the interpretation of 131I-Hippuran studies on newer-generation equipment until revised criteria of interpretation have been established. Non-visualization of the kidney may not have the same prognostic implication using modern cameras as has been reported from studies with older generation detector systems.
最近观察到几名肾衰竭患者，用99锝-二乙三胺五醋酸（99Tcm-DTPA）对其肾脏成像比用131碘-马尿酸（131I-Hippuran）更清晰。我们推测，与老一代相机相比，我们的新一代伽马相机对131I成像的能力有所下降。通过比较具有代表性的老一代和新一代成像系统对这一假设进行了验证。老一代和新一代相机的99Tcm半高宽线扩展函数分别为1.20厘米和1.55厘米。新一代相机上的99Tcm计数率是老一代相机的111%，在模拟多种99Tcm计数分布的体模模型中，两台相机观察到的肾脏与本底计数比几乎相同。老一代和新一代相机上131I的半高宽线扩展分别为1.55厘米和4.78厘米，新一代相机上的131I计数率是老一代系统计数率的27%。体模模型显示，与老一代系统相比，新一代伽马相机上131I的肾脏与本底计数比始终较低。在建立修订的解释标准之前，在新一代设备上进行131I-Hippuran研究的解释中应考虑这些发现。使用现代相机时，肾脏不显影可能没有用老一代探测器系统进行的研究所报告的相同预后意义。
