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采用改良BEACOPP方案对1型脱髓鞘性遗传性运动和感觉神经病（HMSN1）患者进行晚期霍奇金淋巴瘤的有效治疗。

Effective treatment of advanced Hodgkin lymphoma with a modified BEACOPP regimen for a patient with demyelinating hereditary motor and sensory neuropathy type 1 (HMSN1).

作者信息

Hess Patrick P, Ventura Ferreira Monica S, Rolles Benjamin, Kirschner Martin, Holtbernd Florian, Tometten Mareike, Brümmendorf Tim H, Beier Fabian

机构信息

Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation RWTH Aachen University Aachen Germany.

Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD) Aachen Germany.

出版信息

Clin Case Rep. 2022 May 5;10(5):e05766. doi: 10.1002/ccr3.5766. eCollection 2022 May.

DOI:10.1002/ccr3.5766
PMID:35540715
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9069391/
Abstract

Treatment for Hodgkin lymphoma (HL) in adults comprises substantial risk of chemotherapy-induced peripheral neurotoxicity. Here, we describe the case of patient with Charcot-Marie-Tooth disease or HSMN1 and advanced Hodgkin lymphoma undergoing treatment with modified BEACOPP achieving complete remission without major aggravation of neurological symptoms.

摘要

成人霍奇金淋巴瘤（HL）的治疗存在化疗诱导的周围神经毒性的重大风险。在此，我们描述了一名患有夏科-马里-图斯病或遗传性运动感觉神经病1型（HSMN1）且患有晚期霍奇金淋巴瘤的患者，接受改良BEACOPP方案治疗后实现完全缓解，且神经症状未出现重大加重的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e1e/9069391/c1e31b8b7d86/CCR3-10-e05766-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e1e/9069391/78dee96fd000/CCR3-10-e05766-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e1e/9069391/521f116ab357/CCR3-10-e05766-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e1e/9069391/c1e31b8b7d86/CCR3-10-e05766-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e1e/9069391/78dee96fd000/CCR3-10-e05766-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e1e/9069391/521f116ab357/CCR3-10-e05766-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e1e/9069391/c1e31b8b7d86/CCR3-10-e05766-g004.jpg

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本文引用的文献

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Hodgkin Lymphoma: Differences in Treatment Between Europe and the United States/North America: Evolving Trends in Protocol Therapy.霍奇金淋巴瘤：欧洲与美国/北美的治疗差异：方案治疗的发展趋势
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PET 引导治疗晚期霍奇金淋巴瘤（HD18）：德国霍奇金研究组开展的一项开放标签、国际、随机 3 期临床试验的最终结果。
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Severe vincristine-induced polyneuropathy in a teenager with anaplastic medulloblastoma and undiagnosed Charcot-Marie-Tooth disease.一名患有间变性髓母细胞瘤且未被诊断出患有夏科-马里-图思病的青少年出现严重的长春新碱诱导性多发性神经病。
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The genetics of Charcot-Marie-Tooth disease: current trends and future implications for diagnosis and management.夏科-马里-图思病的遗传学：当前趋势及对诊断与管理的未来影响
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