基于生物大环的超分子疏水客体传输系统。

A supramolecular hydrophobic guest transport system based on a biological macrocycle.

作者信息

Ge Yan, Shen Xin, Cao Hongqian, Hao Yuchong, Jin Lin, Shang Jie, Wang Yangxin, Pan Tiezheng, Qi Zhenhui

机构信息

Sino-German Joint Research Lab for Space Biomaterials and Translational Technology, School of Life Sciences, Northwestern Polytechnical University Xi'an Shaanxi 710072 China

Institute of Biomedical Materials & Engineering (IBME), Northwestern Polytechincial University Xi'an Shaanxi 710072 P. R. China.

出版信息

RSC Adv. 2019 Nov 22;9(65):38195-38199. doi: 10.1039/c9ra07054k. eCollection 2019 Nov 19.

A protein-based macrocyclic bioactive guest loading system has been developed, which not only provides a stable 10 nm scale lipophilic environment, but also increases the solubility of potent anticancer agent SN38 in its active lactone form in aqueous medium.