钴催化的烷烃与苯甲酰胺之间的C(sp)-H/C(sp)-H氧化偶联反应。

Li Shuangjie, Wang Bao, Dong Guangyu, Li Chunpu, Liu Hong

School of Pharmacy, China Pharmaceutical University Jiangsu Nanjing 210009 China.

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 555 Zu Chong Zhi Road Shanghai 201203 China.

RSC Adv. 2018 Apr 10;8(24):13454-13458. doi: 10.1039/c8ra01377b. eCollection 2018 Apr 9.

A direct cobalt-catalyzed oxidative coupling between C(sp)-H in unactivated benzamides and C(sp)-H in simple alkanes, ethers and toluene derivatives was explored. This protocol achieves direct C-C formation without using alkyl or aryl halide surrogates and exhibits high practicality with ample substrate scope. The method provides a new way to construct linear and five- or six-membered ring moieties in bioactive molecules.

探索了一种直接钴催化的未活化苯甲酰胺中C(sp)-H与简单烷烃、醚和甲苯衍生物中C(sp)-H之间的氧化偶联反应。该方法无需使用烷基或芳基卤化物替代物即可实现直接的C-C键形成，并且在底物范围广泛的情况下具有很高的实用性。该方法为在生物活性分子中构建线性和五元或六元环部分提供了一种新途径。