Dunn M A, Blalock T L, Cousins R J
Proc Soc Exp Biol Med. 1987 Jun;185(2):107-19. doi: 10.3181/00379727-185-42525a.
Early research on metallothionein centered on aspects related to a detoxification role. As our understanding of the complex endocrine control that regulates metallothionein gene expression increases, a wider appreciation of a functional role(s) is emerging. Medical implications of control of metallothionein turnover include diagnosis of specific diseases and regulation of its expression as a host defense component.
早期对金属硫蛋白的研究集中在与解毒作用相关的方面。随着我们对调节金属硫蛋白基因表达的复杂内分泌控制的理解不断加深,对其功能作用的更广泛认识正在形成。控制金属硫蛋白周转的医学意义包括特定疾病的诊断以及将其作为宿主防御成分的表达调控。