β-烷氧基保护的苯乙胺的合成——一锅法铜催化氮杂环丙烷化和开环反应
Synthesis of β-alkoxy--protected phenethylamines one-pot copper-catalyzed aziridination and ring opening.
作者信息
Saavedra-Olavarría Jorge, Madrid-Rojas Matías, Almodovar Iriux, Hermosilla-Ibáñez Patricio, Pérez Edwin G
机构信息
Department of Organic Chemistry, Faculty of Chemistry, Pontificia Universidad Católica de Chile Av. Vicuña Mackenna 4860, Casilla 306, Correo 22 Santiago Chile
Facultad de Química y Biología, Universidad de Santiago de Chile, USACh Santiago Chile.
出版信息
RSC Adv. 2018 Aug 6;8(49):27919-27923. doi: 10.1039/c8ra03815e. eCollection 2018 Aug 2.
Abstract
A regioselective, copper-catalyzed, one-pot aminoalkoxylation of styrenes using primary and secondary alcohols and three different iminoiodanes as alkoxy and nitrogen sources respectively, is reported. The β-alkoxy--protected phenethylamines obtained were used to synthesise β-alkoxy--benzylphenethylamines which are interesting new compounds that could act as possible neuronal ligands.
摘要
报道了一种区域选择性的、铜催化的、一锅法的苯乙烯氨基烷氧基化反应，该反应分别使用伯醇和仲醇以及三种不同的亚胺碘烷作为烷氧基和氮源。所得到的β-烷氧基保护的苯乙胺被用于合成β-烷氧基苄基苯乙胺，这些是有趣的新化合物，可能作为潜在的神经元配体。
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