转膜丝氨酸蛋白酶 3 mRNA 水平在放射抗拒结直肠癌细胞中的上调。

Upregulation of the transmembrane protease serine 3 mRNA level in radioresistant colorectal cancer tissues.

机构信息

Department of Radiotherapy, The First Affiliated Hospital of Guangxi Medical University, no. 6 Shuangyong Rd, Nanning, Guangxi Zhuang Autonomous Region, 530021, PR China.

Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, no. 6 Shuangyong Rd, Nanning, Guangxi Zhuang Autonomous Region, 530021, PR China.

出版信息

Biomark Med. 2022 Jun;16(9):693-715. doi: 10.2217/bmm-2021-0649. Epub 2022 May 11.

DOI:10.2217/bmm-2021-0649

PMID:35543030

Abstract

To investigate the clinical role of transmembrane protease serine 3 (TMPRSS3) in radioresistance and prognosis of colorectal cancer (CRC). Standardized mean difference (SMD) and summary area under the curve (AUC) of were calculated by combining all available high-throughput data globally. The prognostic significance of was determined by Kaplan-Meier and Cox regression analyses. was remarkably upregulated in 198 CRC radioresistant cases compared with nonradioresistance (SMD = 0.38, AUC = 0.71). Overexpression of was observed in 1601 CRC patients compared with control subjects without CRC. was a risk factor for disease-free survival of CRC with the summarized hazard ratio 1.28. TMPRSS3 contributes to the radioresistance and unfavorable prognosis of CRC.

摘要

研究跨膜丝氨酸蛋白酶 3（TMPRSS3）在结直肠癌（CRC）放射抵抗和预后中的临床作用。通过结合全球所有可用的高通量数据，计算标准化均数差（SMD）和汇总曲线下面积（AUC）。通过 Kaplan-Meier 和 Cox 回归分析确定的预后意义。与非放射抵抗相比，198 例 CRC 放射抵抗病例中显著上调（SMD=0.38，AUC=0.71）。与无 CRC 的对照受试者相比，在 1601 例 CRC 患者中观察到的过表达。是 CRC 无病生存的危险因素，汇总风险比为 1.28。 TMPRSS3 有助于 CRC 的放射抵抗和不良预后。