Gaziev A I, Malakhova L V, Kutsyĭ M P
Radiobiologiia. 1987 Mar-Apr;27(2):166-70.
Proteinase activity of the nuclear matrix of rat hepatocytes was 7-8-times as high as that of initial nuclei. Activity of nuclear matrix proteinases was optimum at pH 8-9. Proteolytic activity associated with the nuclear matrix, increased by 1.4-2.8 times 2 h following irradiation with doses from 5 to 30 Gy. Cycloheximide, a protein synthesis inhibitor, administered to animals failed to suppress the radiation-induced increase of proteinase activity of the nuclear matrix.
大鼠肝细胞核基质的蛋白酶活性比初始细胞核的蛋白酶活性高7 - 8倍。核基质蛋白酶的活性在pH 8 - 9时最佳。与核基质相关的蛋白水解活性，在用5至30 Gy剂量照射后2小时增加了1.4 - 2.8倍。给动物注射蛋白质合成抑制剂环己酰亚胺未能抑制辐射诱导的核基质蛋白酶活性增加。
