小分子神经溶素激活剂，用于缺血性中风治疗的潜在多机制药物。 - Suppr

Small molecule neurolysin activators, potential multi-mechanism agents for ischemic stroke therapy.

作者信息

Esfahani Shiva Hadi, Abbruscato Thomas J, Trippier Paul C, Karamyan Vardan T

机构信息

Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, Amarillo, TX, USA.

Center for Blood Brain Barrier Research, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA.

出版信息

Expert Opin Ther Targets. 2022 May;26(5):401-404. doi: 10.1080/14728222.2022.2077190. Epub 2022 May 19.

DOI:10.1080/14728222.2022.2077190

PMID:35543670

Abstract

摘要

相似文献

Small molecule neurolysin activators, potential multi-mechanism agents for ischemic stroke therapy.小分子神经溶素激活剂，用于缺血性中风治疗的潜在多机制药物。

Expert Opin Ther Targets. 2022 May;26(5):401-404. doi: 10.1080/14728222.2022.2077190. Epub 2022 May 19.

Discovery of First-in-Class Peptidomimetic Neurolysin Activators Possessing Enhanced Brain Penetration and Stability.发现具有增强脑渗透性和稳定性的一流拟肽神经溶素激活剂。

J Med Chem. 2021 Sep 9;64(17):12705-12722. doi: 10.1021/acs.jmedchem.1c00759. Epub 2021 Aug 26.

In-Vivo and Ex-Vivo Brain Uptake Studies of Peptidomimetic Neurolysin Activators in Healthy and Stroke Animals.在健康和中风动物中进行拟肽神经溶解酶激活剂的体内和体外脑摄取研究。

Pharm Res. 2022 Jul;39(7):1587-1598. doi: 10.1007/s11095-022-03218-w. Epub 2022 Mar 3.

Discovery of the Next Generation of Non-peptidomimetic Neurolysin Activators with High Blood-Brain Barrier Permeability: a Pharmacokinetics Study in Healthy and Stroke Animals.发现具有高血脑屏障通透性的新一代非肽拟神经溶解酶激活剂：在健康和中风动物中的药代动力学研究。

Pharm Res. 2023 Nov;40(11):2747-2758. doi: 10.1007/s11095-023-03619-5. Epub 2023 Oct 13.

Structure-activity relationship studies of functionalized aromatic peptidomimetics as neurolysin activators.作为神经氨酸酶激活剂的功能化芳香肽类似物的构效关系研究。

Bioorg Med Chem Lett. 2022 May 15;64:128669. doi: 10.1016/j.bmcl.2022.128669. Epub 2022 Mar 12.

Functional up-regulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain.在实验性中风后急性和早期恢复阶段，神经肽酶神经溶解素在小鼠大脑中的功能上调。

J Neurochem. 2014 Apr;129(1):179-89. doi: 10.1111/jnc.12513. Epub 2013 Nov 19.

Peptidase neurolysin is an endogenous cerebroprotective mechanism in acute neurodegenerative disorders.脑啡肽酶神经溶解素是急性神经退行性疾病中的一种内源性脑保护机制。

Med Hypotheses. 2019 Oct;131:109309. doi: 10.1016/j.mehy.2019.109309. Epub 2019 Jul 13.

Identification and Characterization of Two Structurally Related Dipeptides that Enhance Catalytic Efficiency of Neurolysin.鉴定和表征两种结构相关的二肽，增强神经溶解酶的催化效率。

J Pharmacol Exp Ther. 2021 Nov;379(2):191-202. doi: 10.1124/jpet.121.000840. Epub 2021 Aug 13.

Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification.脱氧hypusine羟化酶作为缺血性中风的新型药理学靶点，通过诱导独特的翻译后hypusination修饰发挥作用。

Pharmacol Res. 2022 Feb;176:106046. doi: 10.1016/j.phrs.2021.106046. Epub 2022 Jan 7.

The role of peptidase neurolysin in neuroprotection and neural repair after stroke.肽酶神经溶素在中风后神经保护和神经修复中的作用。

Neural Regen Res. 2021 Jan;16(1):21-25. doi: 10.4103/1673-5374.284904.

引用本文的文献

Structural basis of divergent substrate recognition and inhibition of human neurolysin.人神经溶素不同底物识别与抑制的结构基础

Sci Rep. 2024 Aug 8;14(1):18420. doi: 10.1038/s41598-024-67639-w.

Imidazole Bioisostere Activators of Endopeptidase Neurolysin with Enhanced Potency and Metabolic Stability.具有增强效力和代谢稳定性的内肽酶神经溶素的咪唑生物电子等排体激活剂。

ACS Med Chem Lett. 2024 Mar 29;15(4):510-517. doi: 10.1021/acsmedchemlett.4c00009. eCollection 2024 Apr 11.

The evolution of small molecule enzyme activators.小分子酶激活剂的演变

RSC Med Chem. 2023 Sep 22;14(11):2206-2230. doi: 10.1039/d3md00399j. eCollection 2023 Nov 15.

Pharm Res. 2023 Nov;40(11):2747-2758. doi: 10.1007/s11095-023-03619-5. Epub 2023 Oct 13.

本文引用的文献

Structure-activity relationship studies of functionalized aromatic peptidomimetics as neurolysin activators.作为神经氨酸酶激活剂的功能化芳香肽类似物的构效关系研究。

Bioorg Med Chem Lett. 2022 May 15;64:128669. doi: 10.1016/j.bmcl.2022.128669. Epub 2022 Mar 12.

Pharm Res. 2022 Jul;39(7):1587-1598. doi: 10.1007/s11095-022-03218-w. Epub 2022 Mar 3.

Discovery of First-in-Class Peptidomimetic Neurolysin Activators Possessing Enhanced Brain Penetration and Stability.发现具有增强脑渗透性和稳定性的一流拟肽神经溶素激活剂。

J Med Chem. 2021 Sep 9;64(17):12705-12722. doi: 10.1021/acs.jmedchem.1c00759. Epub 2021 Aug 26.

J Pharmacol Exp Ther. 2021 Nov;379(2):191-202. doi: 10.1124/jpet.121.000840. Epub 2021 Aug 13.

Neurolysin substrates bradykinin, neurotensin and substance P enhance brain microvascular permeability in a human in vitro model.神经松弛素底物缓激肽、神经降压素和 P 物质增强人脑微血管通透性的体外模型。

J Neuroendocrinol. 2021 Feb;33(2):e12931. doi: 10.1111/jne.12931. Epub 2021 Jan 28.

The role of peptidase neurolysin in neuroprotection and neural repair after stroke.肽酶神经溶素在中风后神经保护和神经修复中的作用。

Neural Regen Res. 2021 Jan;16(1):21-25. doi: 10.4103/1673-5374.284904.

Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice.神经肽酶神经溶解素可防止雄性小鼠中风后脑损伤。

J Neurochem. 2020 Apr;153(1):120-137. doi: 10.1111/jnc.14864. Epub 2019 Oct 22.

Peptidase neurolysin is an endogenous cerebroprotective mechanism in acute neurodegenerative disorders.脑啡肽酶神经溶解素是急性神经退行性疾病中的一种内源性脑保护机制。

Med Hypotheses. 2019 Oct;131:109309. doi: 10.1016/j.mehy.2019.109309. Epub 2019 Jul 13.

Neurolysin: From Initial Detection to Latest Advances.神经溶解酶：从最初的发现到最新进展。

Neurochem Res. 2018 Nov;43(11):2017-2024. doi: 10.1007/s11064-018-2624-6. Epub 2018 Aug 29.

Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin.人线粒体肽酶神经溶解素结合和切割肽的机制。

J Mol Biol. 2018 Feb 2;430(3):348-362. doi: 10.1016/j.jmb.2017.11.011. Epub 2017 Nov 26.

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Small molecule neurolysin activators, potential multi-mechanism agents for ischemic stroke therapy.

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