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一例由镰刀菌属引起的真菌性角膜炎,预后不佳。

A case of mycotic keratitis due to Fusarium sp. with an undesirable outcome.

作者信息

Trenkić Marija, Babić Gordana Stanković, Randelović Marina, Krstić Miljan, Radenković Marija, Tasić-Otašević Suzana

机构信息

Department of Ophthalmology, Faculty of Medicine, University of Niš, Serbia.

Department of Microbiology and Immunology, Faculty of Medicine, University of Niš, Serbia.

出版信息

J Infect Dev Ctries. 2022 Apr 30;16(4):729-732. doi: 10.3855/jidc.15824.

Abstract

Fungal keratitis, an infective disease of the cornea, represents a serious diagnostic and therapeutic problem that, if not recognized on time, could lead to irreversible eye damage. Herein we report a case of fungal keratitis due to Fusarium spp. infection. The 60-year-old man was admitted to our clinic due to an atraumatic acute onset of the disease, with a decrease in the visual acuity, photophobia, redness, and severe pain in the right eye. Clinical observation revealed an ulcer that affected 1/3 of the cornea and a hypopion in the anterior chamber. After the first results of microbiological analyzes, local and systemic antifungal therapy was applied. Due to the fact that the patient voluntarily left the treatment, there was a drastic worsening of the local findings as a full thickness total corneal infiltrate with more intense anterior chamber reaction. Finally, evisceration was performed. Given the fact that fungal keratitis is more prevalent in developing countries, official protocols and available effective antifungals are crucial for adequate treatment and a favorable outcome of this infection.

摘要

真菌性角膜炎是一种角膜感染性疾病,是一个严重的诊断和治疗难题,若不能及时识别,可能导致不可逆的眼部损害。在此,我们报告一例由镰刀菌属感染引起的真菌性角膜炎病例。该60岁男性因无外伤急性起病入院,出现视力下降、畏光、眼红及右眼剧痛。临床检查发现角膜溃疡累及角膜的1/3,前房有积脓。微生物分析初检结果出来后,给予局部和全身抗真菌治疗。由于患者自行中断治疗,局部病情急剧恶化,出现全层角膜全层浸润,前房反应更强烈。最终,实施了眼球内容剜除术。鉴于真菌性角膜炎在发展中国家更为普遍,官方诊疗方案和有效的抗真菌药物对于充分治疗该感染及取得良好疗效至关重要。

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