First College of Clinical Medical Science, China Three Gorges University; Institute of Digestive Disease, China Three Gorges University; Department of Gastroenterology, Yichang Central People's Hospital, Yichang Hubei 443000, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Mar 28;47(3):364-373. doi: 10.11817/j.issn.1672-7347.2022.210118.
Hepatocellular carcinoma is one of the most common malignant tumors in the world. Although there are many options for the treatment of hepatocellular carcinoma, such as surgical resection, interventional therapy, radiotherapy, chemotherapy, targeted therapy and liver transplantation, the poor therapeutic effect seriously reduces the quality of life for patients and also increases the social and economic burden. Metformin is originally used as the first-line drug for type 2 diabetes, but it has been found to play a certain effect in the prevention and treatment of malignant tumor. The potential roles of metformin against hepatocellular carcinoma, such as regulation of the microenvironment, proliferation signal pathway, metabolism, invasion and metastasis, apoptosis, autophagy, and epigenetics of hepatoma cells. It provides a new choice for the prevention and treatment of hepatocellular carcinoma.
肝细胞癌是世界上最常见的恶性肿瘤之一。尽管肝细胞癌的治疗方法有很多，如手术切除、介入治疗、放疗、化疗、靶向治疗和肝移植等，但治疗效果不佳，严重降低了患者的生活质量，也增加了社会和经济负担。二甲双胍最初是作为 2 型糖尿病的一线药物使用，但现已发现其在恶性肿瘤的防治中具有一定作用。二甲双胍对肝细胞癌的潜在作用，如调节微环境、增殖信号通路、代谢、侵袭和转移、细胞凋亡、自噬以及肝癌细胞的表观遗传学等，为肝细胞癌的防治提供了新的选择。
