Emerging Liquid Metal Biomaterials: From Design to Application.

Liquid metals (LMs) as emerging biomaterials possess unique advantages including their favorable biosafety, high fluidity, and excellent electrical and thermal conductivities, thus providing a unique platform for a wide range of biomedical applications ranging from drug delivery, tumor therapy, and bioimaging to biosensors. The structural design and functionalization of LMs endow them with enhanced functions such as enhanced targeting ability and stimuli responsiveness, enabling them to achieve better and even multifunctional synergistic therapeutic effects. Herein, the advantages of LMs in biomedicine are presented. The design of LM-based biomaterials with different scales ranging from micro-/nanoscale to macroscale and various components is explored in-depth to promote the understanding of structure-property relationships, guiding their performance optimization and applications. Furthermore, the related advanced progress in the development of LM-based biomaterials in biomedicine is summarized. Current challenges and prospects of LMs in the biomedical field are also discussed.