Meena Neha, Dhiman Shiv, Rangan Krishnan, Kumar Anil
Department of Chemistry, Birla Institute of Technology and Science, Pilani, Rajasthan 333031, India.
Department of Chemistry, Birla Institute of Technology and Science Pilani, Hyderabad Campus, Telangana, 500078, India.
Org Biomol Chem. 2022 May 26;20(20):4215-4223. doi: 10.1039/d2ob00526c.
An efficient cobalt-catalyzed tandem one-pot method has been developed for the synthesis of polysubstituted imidazo[1,5-]-N-heteroaromatics. The method involves Knoevenagel condensation followed by cobalt-catalyzed direct alkenylation to give the desired polysubstituted imidazo[1,5-]pyridines and imidazo[1,5-]isoquinolines in a one-pot manner. This method exhibits a broad substrate scope, provides moderate to good (39-74%) yields and is amenable to scale-up to the gram scale.
已开发出一种高效的钴催化串联一锅法来合成多取代咪唑并[1,5 - ] - N - 杂芳烃。该方法包括克诺文纳格尔缩合反应，随后是钴催化的直接烯基化反应，以一锅法得到所需的多取代咪唑并[1,5 - ]吡啶和咪唑并[1,5 - ]异喹啉。该方法具有广泛的底物范围，产率适中至良好（39 - 74%），并且适合放大至克级规模。
