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[控制生酮饮食儿童抗癫痫药物中的碳水化合物含量]

[Controlling carbohydrate content in antiepileptic medications for children on a ketogenic diet].

作者信息

Martín Prado Silvia, Pozas Del Río Maite, Cañedo Villarroya Elvira, Pedrón Giner Consuelo

机构信息

Servicio de Farmacia Hospitalaria. Hospital Infantil Universitario Niño Jesús.

Sección de Gastroenterología y Nutrición. Hospital Infantil Universitario Niño Jesús.

出版信息

Nutr Hosp. 2022 Aug 25;39(4):760-777. doi: 10.20960/nh.04036.

Abstract

Introduction: patients who follow a ketogenic diet for the control of epileptic seizures must carry out a strict control of carbohydrates from the foods they eat and the medicines they are prescribed. In the initiation of a ketogenic diet and when a doctor prescribes a new medication, it is necessary to select the most appropriate pharmaceutical form so that the supply of excipients in the form of carbohydrates from the drugs is minimized. Objectives: the goal of the present paper was to compile a list of carbohydrate and caloric contents in antiepileptic drugs commonly used in pediatric neurology. Methods: in each medication included in the list, the content of excipients considered carbohydrates and derivatives that could influence the patient's ketosis was reviewed. The caloric content from carbohydrates and polyols in each medication was calculated. Results: the table provides the total carbohydrate and caloric content for antiepileptic medications in pediatric patients consuming the ketogenic diet. Conclusions: this table is intended to be a useful tool to help clinicians select a pharmaceutical form that is less likely to affect the ketogenic diet. Additionally, knowing the carbohydrate content of a new medication will allow adjustment of the diet to maintain ketosis.

摘要

引言

采用生酮饮食控制癫痫发作的患者必须严格控制所吃食物和所开药物中的碳水化合物。在开始生酮饮食以及医生开新药时,有必要选择最合适的剂型,以使药物中碳水化合物形式的辅料供应降至最低。目的:本文的目的是汇编一份儿科神经学常用抗癫痫药物中碳水化合物和热量含量的清单。方法:在清单中的每种药物中,审查了被视为碳水化合物的辅料以及可能影响患者酮症的衍生物的含量。计算了每种药物中碳水化合物和多元醇的热量含量。结果:该表提供了食用生酮饮食的儿科患者抗癫痫药物的总碳水化合物和热量含量。结论:该表旨在成为一个有用的工具,帮助临床医生选择不太可能影响生酮饮食的剂型。此外,了解新药的碳水化合物含量将有助于调整饮食以维持酮症。

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