寡肽转运蛋白：PEPT1 在肿瘤中的表达、调控及作用。
Expression, Regulation, and Role of an Oligopeptide Transporter: PEPT1 in Tumors.
机构信息
Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin Institute of Digestive Disease, Tianjin 300052, China.
Tianjin Baodi Hospital/Baodi Clinical College of Tianjin Medical University, Tianjin 300052, China.
出版信息
Curr Med Chem. 2022;29(9):1596-1605. doi: 10.2174/0929867328666210707170214.
PEPT1 is a vital member of the proton-dependent oligopeptide transporters family (POTs). Many studies have confirmed that PEPT1 plays a critical role in the absorption of dipeptides, tripeptides, and pseudopeptides in the intestinal tract. In recent years, several studies have found that PEPT1 is highly expressed in malignant tumor tissues and cells. The abnormal expression of PEPT1 in tumors may be closely related to the progress of tumors, and hence, could be considered as a potential molecular biomarker for the diagnosis, treatment, and prognosis in malignant tumors. Furthermore, PEPT1 can be used to mediate the targeted delivery of anti-tumor drugs. Herein, the expression, regulation, and role of PEPT1 in tumors in recent years have been reviewed.
PEPT1 是质子依赖的寡肽转运体家族（POTs）中的重要成员。许多研究证实，PEPT1 在肠道中对二肽、三肽和假肽的吸收起着关键作用。近年来，一些研究发现 PEPT1 在恶性肿瘤组织和细胞中高度表达。肿瘤中 PEPT1 的异常表达可能与肿瘤的进展密切相关，因此可以将其视为恶性肿瘤诊断、治疗和预后的潜在分子生物标志物。此外，PEPT1 可用于介导抗肿瘤药物的靶向递送。本文就近年来 PEPT1 在肿瘤中的表达、调控及其作用进行综述。
Zotero 插件