Department of Pulmonology, Hacettepe University Hospital, Ankara, Turkey.
Department of Pulmonology, Balikesir State Hospital, Balıkesir, Turkey.
J Coll Physicians Surg Pak. 2022 May;32(5):606-612. doi: 10.29271/jcpsp.2022.05.606.
To investigate the prognostic importance of pulmonary functions and their effect on survival in patients with operable non-small cell lung cancer (NSCLC), who underwent surgical resection and/or received medical treatment.
Cohort study.
University of Health Sciences, Diskapi Training and Research Hospital, Ankara, Turkey, between June 2013 and March 2020.
The study included a total of 70 patients diagnosed with non-small cell lung cancer (NSCLC), comprising 35 who underwent surgical treatment and 35 who were treated medically. The effects of age, gender, additional comorbidities, smoking status, complications after surgery and/or radiotherapy, and pulmonary function test values on survival were investigated.
The median overall survival time of the patients was 1973±769.1 (466-3.480) days. According to the univariate Cox regression analysis, the preoperative and postoperative values of the forced expiratory volume in 1 second were not important risk factors affecting survival (p=0.752 and p=0.878) respectively. A statistically significant difference was observed in survival probability between the patients with and without coronary artery disease (CAD) (p=0.005). There was also a statistically significant difference between the Eastern Cooperative Oncology Group (ECOG) performance groups in terms of survival probability (p<0.001).
There was no relationship between pulmonary functions and survival in patients with operable NSCLC, but this evaluation should be undertaken in larger patient groups. This study demonstrated the importance of patients' performance status and comorbidities, such as CAD in survival.
Non-small cell lung cancer, Survival, Respiratory function test.
探讨可手术非小细胞肺癌（NSCLC）患者手术切除和/或接受治疗后肺功能对生存的预后意义。
队列研究。
土耳其安卡拉健康科学大学 Diskapi 培训与研究医院，2013 年 6 月至 2020 年 3 月。
本研究共纳入 70 例非小细胞肺癌（NSCLC）患者，其中 35 例行手术治疗，35 例行内科治疗。研究调查了年龄、性别、合并症、吸烟状况、手术和/或放疗后并发症以及肺功能检查值对生存的影响。
患者的中位总生存时间为 1973±769.1（466-3.480）天。单因素 Cox 回归分析显示，1 秒用力呼气量的术前和术后值不是影响生存的重要危险因素（p=0.752 和 p=0.878）。有和无冠状动脉疾病（CAD）的患者之间的生存概率存在统计学显著差异（p=0.005）。ECOG 表现组之间的生存概率也存在统计学显著差异（p<0.001）。
可手术 NSCLC 患者的肺功能与生存之间无相关性，但这一评估应在更大的患者群体中进行。本研究表明，患者的体能状态和合并症（如 CAD）对生存很重要。
非小细胞肺癌；生存；呼吸功能试验。
