该通路中的多态性与焦炉工人的线粒体DNA拷贝数相关。
The polymorphisms in pathway are associated with mitochondrial DNA copy number in coke oven workers.
作者信息
Liu Xiaohua, Li Xinling, Wei Wan, Fan Yahui, Guo Zhifeng, Duan Xiaoran, Zhou Xiaoshan, Yang Yongli, Wang Wei
机构信息
Department of Occupational health and Occupational diseases, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
出版信息
Int J Environ Health Res. 2023 Nov;33(11):1070-1080. doi: 10.1080/09603123.2022.2071418. Epub 2022 May 11.
OBJECTIVE
To evaluate the interaction effects of Polycyclic aromatic hydrocarbons (PAHs) exposure and variants in genes on mitochondrial DNA copy number (mtDNAcn) in workers.
METHODS
The mtDNAcn was determined by real-time quantitative polymerase-chain reaction in 544 PAHs-exposed workers and 238 office workers. The polymorphisms were detected by flight mass spectrometry.
RESULTS
The mtDNAcn in PAHs exposure group was significantly lower than non-occupational exposure population ( < 0.00). The cGAS rs610913 CA+AA had significant interaction effects with STING rs11554776 GG+GA ( = 0.035), rs7380824 CC+CT ( = 0.026), and rs78233829 GC+CC ( = 0.034) on mtDNAcn. The generalized linear model results showed that the influencing factors of mtDNAcn include PAHs exposure ( < 0.001) and the interaction of PAHs exposure and 311678 AA+AG ( = 0.047).
CONCLUSION
The influencing factors of mtDNAcn include PAHs exposure and the interaction of PAHs exposure and 311678 AA+AG.
目的
评估多环芳烃（PAHs）暴露与基因变异对工人线粒体DNA拷贝数（mtDNAcn）的交互作用。
方法
采用实时定量聚合酶链反应测定544名PAHs暴露工人和238名办公室工作人员的mtDNAcn。通过飞行质谱法检测基因多态性。
结果
PAHs暴露组的mtDNAcn显著低于非职业暴露人群（<0.00）。cGAS rs610913 CA+AA与STING rs11554776 GG+GA（=0.035）、rs7380824 CC+CT（=0.026）和rs78233829 GC+CC（=0.034）对mtDNAcn有显著交互作用。广义线性模型结果显示，mtDNAcn的影响因素包括PAHs暴露（<0.001）以及PAHs暴露与311678 AA+AG的交互作用（=0.047）。
结论
mtDNAcn的影响因素包括PAHs暴露以及PAHs暴露与311678 AA+AG的交互作用。
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