早期异常行为作为精神分裂症的维度特质和内表型
Early deviant behaviour as a dimension trait and endophenotype in schizophrenia.
作者信息
Roos Johannes L, Kotzé Carla
机构信息
Department of Psychiatry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Weskoppies Psychiatric Hospital, Pretoria, South Africa.
出版信息
S Afr J Psychiatr. 2022 Apr 29;28:1747. doi: 10.4102/sajpsychiatry.v28i0.1747. eCollection 2022.
BACKGROUND
In psychiatry, there is still a lack of objective biological diagnostic measurements. It is important to investigate measurements or symptom dimensions that can inform diagnostic assessments and allow for a more personalised approach to patients.
AIM
To discuss how early deviant behaviour (EDB) may be seen as a possible continuous symptom dimension trait and endophenotype in schizophrenia.
METHODS
Conducting a commentary review by highlighting some important findings from available literature.
RESULTS
Findings regarding EDB in schizophrenia in a South African genetic sample point towards EDB as a progressive subtype of schizophrenia, with very early onset of illness (even prior to the psychotic symptomatology) and a genetic form of illness.
CONCLUSION
Valuable information can be gained by enquiring into EDB and viewing it as a continuous symptom dimension trait and endophenotype during the psychiatric diagnostic interview.
背景
在精神病学领域，仍缺乏客观的生物学诊断指标。研究能够为诊断评估提供信息并使患者治疗更具个性化的指标或症状维度非常重要。
目的
探讨早期异常行为（EDB）如何被视为精神分裂症中一种可能的连续性症状维度特征和内表型。
方法
通过突出现有文献中的一些重要发现进行述评。
结果
在南非一个遗传样本中关于精神分裂症患者早期异常行为的研究结果表明，早期异常行为是精神分裂症的一种进行性亚型，发病极早（甚至早于精神病性症状）且具有遗传形式。
结论
在精神科诊断访谈中，通过询问早期异常行为并将其视为连续性症状维度特征和内表型，可以获得有价值的信息。
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