冬凌草甲素的结构修饰：DAST引发重排反应。

Structural modification of oridonin DAST induced rearrangement.

作者信息

Luo Dong-Dong, Peng Kai, Yang Jia-Yu, Piyachaturawat Pawinee, Saengsawang Witchuda, Ao Lei, Zhao Wan-Zhou, Tang Yu, Wan Sheng-Biao

机构信息

Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China Yushan Road 5 Qingdao 266003 China

Department of Physiology, Faculty of Science, Mahidol University Bangkok 10400 Thailand.

出版信息

RSC Adv. 2018 Aug 20;8(52):29548-29554. doi: 10.1039/c8ra05728a.

A simple and efficient protocol was developed for the syntheses of oridonin analogues, 6,20-epoxy -kaurane diterpenoid analogues from oridonin diethylaminosulfur trifluoride (DAST) promoted rearrangement, most of which exhibited superior anticancer activities compared with their precursor.