Possick Zoe, Alster Tina S
Washington Institute of Dermatologic Laser Surgery, Washington, DC, USA.
Clin Cosmet Investig Dermatol. 2022 May 5;15:823-827. doi: 10.2147/CCID.S357282. eCollection 2022.
Cowden's syndrome is a genetic disorder characterized by multiple oral hamartomas and an increased risk of internal malignancy. These mucocutaneous lesions can be physically disfiguring and psychologically distressing. As a result, patients frequently seek treatment for their destruction. Removal of oral hamartomas is often a challenge due to their sensitive location and high risk of recurrence.
To review the clinical use, effectiveness, and safety of a fractional ablative laser to treat multiple oral hamartomas in a patient with Cowden's syndrome.
A thorough literature review pertaining to treatment of oral hamartomas and a discussion of an illustrative case showcasing successful lesional destruction with a fractional ablative carbon dioxide (CO) laser in a 33-year-old man with Cowden's syndrome.
Multiple oral hamartomas were effectively removed with fractional CO laser vaporization. No infection, scarring, dermatitis, nor lesional recurrence were observed 6 months post-treatment.
Fractional CO laser vaporization can be used effectively to treat multiple oral hamartomas associated with Cowden's syndrome.
考登综合征是一种遗传性疾病，其特征为多发性口腔错构瘤以及发生内脏恶性肿瘤的风险增加。这些皮肤黏膜病变会造成身体外观受损并带来心理困扰。因此，患者常常会寻求针对这些损害的治疗。由于口腔错构瘤位置敏感且复发风险高，切除它们往往具有挑战性。
回顾剥脱性点阵激光治疗考登综合征患者多发性口腔错构瘤的临床应用、有效性及安全性。
对有关口腔错构瘤治疗的文献进行全面综述，并讨论一个说明性病例，该病例展示了一名33岁考登综合征男性患者使用剥脱性二氧化碳（CO）点阵激光成功破坏病变组织的情况。
使用CO点阵激光汽化有效地切除了多发性口腔错构瘤。治疗后6个月未观察到感染、瘢痕形成、皮炎或病变复发。
CO点阵激光汽化可有效用于治疗与考登综合征相关的多发性口腔错构瘤。
