Thankachan Jerrin Mathew, Setty Subba Rao Gangi
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Front Cell Dev Biol. 2022 Apr 25;10:877532. doi: 10.3389/fcell.2022.877532. eCollection 2022.
Molecular motors of the kinesin superfamily (KIF) are a class of ATP-dependent motor proteins that transport cargo, including vesicles, along the tracks of the microtubule network. Around 45 KIF proteins have been described and are grouped into 14 subfamilies based on the sequence homology and domain organization. These motors facilitate a plethora of cellular functions such as vesicle transport, cell division and reorganization of the microtubule cytoskeleton. Current studies suggest that KIF13A, a kinesin-3 family member, associates with recycling endosomes and regulates their membrane dynamics (length and number). KIF13A has been implicated in several processes in many cell types, including cargo transport, recycling endosomal tubule biogenesis, cell polarity, migration and cytokinesis. Here we describe the recent advances in understanding the regulatory aspects of KIF13A motor in controlling the endosomal dynamics in addition to its structure, mechanism of its association to the membranes, regulators of motor activity, cell type-specific cargo/membrane transport, methods to measure its activity and its association with disease. Thus, this review article will provide our current understanding of the cell biological roles of KIF13A in regulating endosomal membrane remodeling.
驱动蛋白超家族（KIF）的分子马达是一类依赖ATP的马达蛋白，它们沿着微管网络的轨道运输包括囊泡在内的货物。已描述了约45种KIF蛋白，并根据序列同源性和结构域组织将其分为14个亚家族。这些马达促进了大量细胞功能，如囊泡运输、细胞分裂和微管细胞骨架的重组。目前的研究表明，驱动蛋白-3家族成员KIF13A与回收型内体相关联，并调节其膜动力学（长度和数量）。KIF13A参与了多种细胞类型中的多个过程，包括货物运输、回收型内体小管生物发生、细胞极性、迁移和胞质分裂。在此，我们描述了在理解KIF13A马达在控制内体动力学方面的调节作用方面的最新进展，此外还介绍了其结构、与膜的结合机制、马达活性的调节因子、细胞类型特异性货物/膜运输、测量其活性的方法及其与疾病的关联。因此，这篇综述文章将阐述我们目前对KIF13A在调节内体膜重塑中的细胞生物学作用的理解。
