Yousefi Hassan, Fong Jordyn, Alahari Suresh K
Department of Biochemistry and Molecular Biology, Louisiana State University Health Science Center (LSUHSC), New Orleans, LA, United States.
Stanley S. Scott Cancer Research Center, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Front Oncol. 2022 Apr 25;12:777824. doi: 10.3389/fonc.2022.777824. eCollection 2022.
This report analyzes nuclear receptor (NR) subfamily 4A's potential role in treating those diagnosed with breast cancer. Here we reviewed the current literature on NR4 family members. We also examined the relative gene expression of the NR4A receptor subfamily in the basal, HER2 (human epidermal growth factor receptor 2) positive, luminal A, and luminal B subtypes using data from tumor samples in The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC). These data showed a positive link between NR4A1-NR4A3 expression and increased overall survival and relapse-free survival in breast cancer patients. In addition, we observed that high expression of NR4A1, NR4A2, and NR4A3 led to better survival. Furthermore, NR4A family genes seem to play an essential regulatory role in glycolysis and oxidative phosphorylation in breast cancer. The novel prognostic role of the NR4A1-NR4A3 receptors implicates these receptors as important mediators controlling breast cancer metabolic reprograming and its progression. The review establishes a strong clinical basis for the investigation of the cellular, molecular, and physiological roles of NR4A genes in breast cancer.
本报告分析了核受体（NR）4A亚家族在治疗乳腺癌患者中的潜在作用。在此，我们回顾了关于NR4家族成员的现有文献。我们还利用来自癌症基因组图谱（TCGA）和国际乳腺癌分子分类联盟（METABRIC）的肿瘤样本数据，检测了NR4A受体亚家族在基底型、HER2（人表皮生长因子受体2）阳性、管腔A型和管腔B型亚型中的相对基因表达。这些数据显示，NR4A1 - NR4A3的表达与乳腺癌患者总生存期和无复发生存期的延长呈正相关。此外，我们观察到NR4A1、NR4A2和NR4A3的高表达导致更好的生存。此外，NR4A家族基因似乎在乳腺癌的糖酵解和氧化磷酸化过程中发挥重要的调节作用。NR4A1 - NR4A3受体的新预后作用表明这些受体是控制乳腺癌代谢重编程及其进展的重要介质。该综述为研究NR4A基因在乳腺癌中的细胞、分子和生理作用奠定了坚实的临床基础。
