在阳离子胶束介质中使用新型硫属元素-香豆素衍生物检测硫氧化物衍生物：在实际样品中的应用
Detection of SO derivatives using a new chalco-coumarin derivative in cationic micellar media: application to real samples.
作者信息
Gómez Marisol, Aliaga Margarita E, Arancibia Verónica, Moya Alexis, Segura Camilo, Nuñez Marco T, Aguirre Pabla, Nagles Edgar, García-Beltrán Olimpo
机构信息
Facultad de Química, Pontificia Universidad Católica de Chile Vicuña Mackenna 4860 Santiago 7820436 Chile.
Escuela de Obstetricia y Puericultura and Centro Integrativo de Biología y Química Aplicada (CIBQA), Universidad Bernardo OHiggins General Gana 1702 Santiago 8370993 Chile.
出版信息
RSC Adv. 2018 Sep 5;8(55):31261-31266. doi: 10.1039/c8ra04526g.
A new probe ()-7-(diethylamino)-3-(3-(thiophen-2-yl)acryloyl)-2-chromen-2-one (ChC16) was synthesized and studied as a turn-on fluorescent probe, based on a Michael addition mechanism for sensing SO derivatives, which is favored in the presence of cationic micellar media such as cetylpyridinium bromide (CPB). The probe showed high selectivity and sensitivity toward bisulfite over other anions and biothiols, including cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), with a detection limit of 240 nM. Moreover, the probe showed great potential for its practical application in the detection of bisulfite in real samples, such as dry white wine, and in bioimaging.
合成了一种新型探针()-7-(二乙氨基)-3-(3-(噻吩-2-基)丙烯酰基)-2-色烯-2-酮(ChC16)，并将其作为一种开启型荧光探针进行研究，该探针基于迈克尔加成机制来传感SO衍生物，在阳离子胶束介质如十六烷基溴化吡啶(CPB)存在的情况下这种机制更有利。该探针对亚硫酸氢盐表现出高于其他阴离子和生物硫醇(包括半胱氨酸(Cys)、高半胱氨酸(Hcy)和谷胱甘肽(GSH))的高选择性和灵敏度，检测限为240 nM。此外，该探针在实际样品(如干白葡萄酒)中亚硫酸氢盐的检测以及生物成像方面具有很大的实际应用潜力。
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