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靶向HMGA蛋白可抑制视网膜母细胞瘤细胞增殖。

Targeting HMGA protein inhibits retinoblastoma cell proliferation.

作者信息

Balachandran Akilandeswari, Zambre Ajit, Kainth Jagjot Singh, Nagarajha Selvan Lakshmi Dhevi, Parameswaran Sowmya, Afrasiabi Zahra, Krishnakumar Subramanian, Kannan Raghuraman, Upendran Anandhi

机构信息

Department of Nanobiotechnology, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology Chennai India

Department of Radiology, University of Missouri Columbia MO USA

出版信息

RSC Adv. 2018 Sep 7;8(55):31510-31514. doi: 10.1039/c8ra06026f. eCollection 2018 Sep 5.

DOI:10.1039/c8ra06026f
PMID:35548247
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9085636/
Abstract

We describe a novel synthetic strategy for conjugating HMGA2 siRNA and the HMGA aptamer to the nucleolin aptamer and nucleolin antibody, respectively. Our studies demonstrate that these conjugates inhibit cell proliferation in retinoblastoma cells.

摘要

我们描述了一种新颖的合成策略，分别将HMGA2小干扰RNA（siRNA）和HMGA适配体与核仁素适配体和核仁素抗体偶联。我们的研究表明，这些偶联物可抑制视网膜母细胞瘤细胞的增殖。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/9085636/0cb6234d002f/c8ra06026f-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/9085636/929c687575df/c8ra06026f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/9085636/200737b3966a/c8ra06026f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/9085636/b28150ba4090/c8ra06026f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/9085636/2fa404a2e8f5/c8ra06026f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/9085636/0cb6234d002f/c8ra06026f-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/9085636/929c687575df/c8ra06026f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/9085636/200737b3966a/c8ra06026f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/9085636/b28150ba4090/c8ra06026f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/9085636/2fa404a2e8f5/c8ra06026f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/9085636/0cb6234d002f/c8ra06026f-f5.jpg

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本文引用的文献

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Cancer Res. 2018 Feb 1;78(3):798-808. doi: 10.1158/0008-5472.CAN-17-2880. Epub 2017 Dec 7.
2
Aptamer-Drug Conjugates of Active Metabolites of Nucleoside Analogs and Cytotoxic Agents Inhibit Pancreatic Tumor Cell Growth.核苷类似物和细胞毒性药物活性代谢物的适配体-药物偶联物可抑制胰腺肿瘤细胞生长。
Mol Ther Nucleic Acids. 2017 Mar 17;6:80-88. doi: 10.1016/j.omtn.2016.11.008. Epub 2016 Dec 10.
3
Acute Hemorrhagic Retinopathy following Intravitreal Melphalan Injection for Retinoblastoma: A Report of Two Cases and Technical Modifications to Enhance the Prevention of Retinal Toxicity.
通过细胞 SELEX 技术筛选针对视网膜母细胞瘤的 DNA 适体的开发和鉴定。
Sci Rep. 2022 Sep 28;12(1):16178. doi: 10.1038/s41598-022-20660-3.
4
Review: New horizons in retinoblastoma treatment: an updated review article.综述：视网膜母细胞瘤治疗的新视野：一篇更新的综述文章。
Mol Vis. 2022 Jul 11;28:130-146. eCollection 2022.
玻璃体内注射美法仑治疗视网膜母细胞瘤后发生的急性出血性视网膜病变：两例报告及增强预防视网膜毒性的技术改进
Ocul Oncol Pathol. 2017 Jan;3(1):34-40. doi: 10.1159/000448718. Epub 2016 Sep 14.
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5
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