靶向HMGA蛋白可抑制视网膜母细胞瘤细胞增殖。
Targeting HMGA protein inhibits retinoblastoma cell proliferation.
作者信息
Balachandran Akilandeswari, Zambre Ajit, Kainth Jagjot Singh, Nagarajha Selvan Lakshmi Dhevi, Parameswaran Sowmya, Afrasiabi Zahra, Krishnakumar Subramanian, Kannan Raghuraman, Upendran Anandhi
机构信息
Department of Nanobiotechnology, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology Chennai India
Department of Radiology, University of Missouri Columbia MO USA
出版信息
RSC Adv. 2018 Sep 7;8(55):31510-31514. doi: 10.1039/c8ra06026f. eCollection 2018 Sep 5.
We describe a novel synthetic strategy for conjugating HMGA2 siRNA and the HMGA aptamer to the nucleolin aptamer and nucleolin antibody, respectively. Our studies demonstrate that these conjugates inhibit cell proliferation in retinoblastoma cells.
我们描述了一种新颖的合成策略，分别将HMGA2小干扰RNA（siRNA）和HMGA适配体与核仁素适配体和核仁素抗体偶联。我们的研究表明，这些偶联物可抑制视网膜母细胞瘤细胞的增殖。
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