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过渡金属/布朗斯特酸协同催化能够通过邻氨基酚、醛和炔烃的一锅反应轻松合成8-羟基喹啉。

Transition metal/Brønsted acid cooperative catalysis enabled facile synthesis of 8-hydroxyquinolines through one-pot reactions of -aminophenol, aldehydes and alkynes.

作者信息

Yu Shuyan, Wu Jingxin, Lan Hongbing, Xu Hanwen, Shi Xiaofei, Zhu Xuewen, Yin Zhigang

机构信息

Material and Chemical Engineering College, Zhengzhou University of Light Industry Zhengzhou 450002 Henan People's Republic of China.

出版信息

RSC Adv. 2018 Oct 3;8(59):33968-33971. doi: 10.1039/c8ra07212d. eCollection 2018 Sep 28.

DOI:10.1039/c8ra07212d
PMID:35548801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9086736/
Abstract

A convenient and straightforward three-component one-pot strategy has been developed for the synthesis of 8-hydroxyquinoline derivatives. Under the cooperative catalysis of silver(i) triflate and trifluoroacetic acid, -aminophenol reacted with a range of aldehydes and alkynes under mild reactions, affording the corresponding 8-hydroxyquinoline derivatives with good to excellent yields. These transformations exhibited exceptional substrate generality and functional group compatibility.

摘要

已开发出一种简便直接的三组分一锅法策略用于合成8-羟基喹啉衍生物。在三氟甲磺酸银（I）和三氟乙酸的协同催化下，邻氨基酚在温和反应条件下与一系列醛和炔烃反应，以良好至优异的产率得到相应的8-羟基喹啉衍生物。这些转化表现出优异的底物通用性和官能团兼容性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31c0/9086736/16647c9f8db8/c8ra07212d-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31c0/9086736/16647c9f8db8/c8ra07212d-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31c0/9086736/16647c9f8db8/c8ra07212d-s1.jpg

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RSC Adv. 2020 Jan 29;10(9):4876-4898. doi: 10.1039/c9ra09905k.
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