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含杂环骨架的新型环肽的合成。

Synthesis of novel cyclopeptides containing heterocyclic skeletons.

作者信息

Hamdan Fatima, Tahoori Fatemeh, Balalaie Saeed

机构信息

Peptide Chemistry Research Center, K. N. Toosi University of Technology P. O. Box 15875-4416 Tehran Iran

Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO) Karaj Iran.

出版信息

RSC Adv. 2018 Oct 3;8(59):33893-33926. doi: 10.1039/c8ra03899f. eCollection 2018 Sep 28.

DOI:10.1039/c8ra03899f
PMID:35548835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9086729/
Abstract

Cyclopeptides can be considered as naturally biologically active compounds. Over the last several decades, many attempts have been made to synthesize complex naturally occurring cyclopeptides, and great progress has been achieved to advance the field of total synthesis. Moreover, cyclopeptides containing heterocyclic skeletons have been recently developed into powerful reactions and approaches. This review aims to highlight recent advances in the synthesis of cyclopeptides containing heterocyclic skeletons such as triazole, oxazole, thiazole, and tetrazole.

摘要

环肽可被视为天然生物活性化合物。在过去几十年中，人们进行了许多尝试来合成复杂的天然存在的环肽，并且在推进全合成领域方面取得了巨大进展。此外，含有杂环骨架的环肽最近已发展成为强大的反应和方法。本综述旨在突出含有三唑、恶唑、噻唑和四唑等杂环骨架的环肽合成方面的最新进展。

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Yao Xue Xue Bao. 2012 Mar;47(3):271-9.
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Parallel synthesis of peptide-like macrocycles containing imidazole-4,5-dicarboxylic acid.含咪唑-4,5-二羧酸的肽类大环的平行合成。
Molecules. 2012 May 8;17(5):5346-62. doi: 10.3390/molecules17055346.
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Braces for the peptide backbone: insights into structure-activity relationships of protease inhibitor mimics with locked amide conformations.肽主链的支撑结构：对具有锁定酰胺构象的蛋白酶抑制剂模拟物构效关系的见解。
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