Department of Oral Biology, The Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, The Center for Physics & Chemistry of Living Systems, and the Center for Nanoscience and Nanotechnology, Tel-Aviv University, 69978, Israel.
Dept. of Med. Chem, NIPER Mohali, S.A.S. Nagar, Mohali, 160062, India.
Chem Commun (Camb). 2022 May 30;58(44):6445-6448. doi: 10.1039/d2cc01038k.
The occurrence of sequential multiple aromatic residues in a helical sequence is rare compared to the β-sheet rich structure. Here, using helix promoting α-aminoisobutyric acid (Aib) residues, we unravel atomistic details of the helical secondary structure formation and the super helical assembly of two heptapeptides composed of sequential five and six phenylalanine (Phe) residues.
与富含β-折叠结构的蛋白质相比，在螺旋序列中连续出现多个芳香族残基的情况较为少见。在这里，我们使用螺旋促进α-氨基异丁酸（Aib）残基，揭示了由连续五个和六个苯丙氨酸（Phe）残基组成的两个七肽的螺旋二级结构形成和超螺旋组装的原子细节。
