Department of Pediatrics, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
Department of Obstetric and Gynecology, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
Gynecol Endocrinol. 2022 Jun;38(6):495-498. doi: 10.1080/09513590.2022.2073347. Epub 2022 May 12.
The aim of this prospective study was to describe demographic and clinical characteristics of neonates born to mothers with active or past Graves disease and to assess compliance since implementation of a new protocol in our center.
We prospectively followed up neonates born to mothers with active or past Graves disease in a tertiary hospital in Spain between August 2019 and September 2021 according to our protocol. We reviewed maternal and neonatal history of these neonates, and we followed up newborns at risk of neonatal hyperthyroidism.
Among 5808 births, 33 neonates were born to mothers with active or past Graves disease (0.57%). Six mothers (18.2%) had positive levels of thyroid-stimulating hormone receptor antibodies during pregnancy and five mothers (15.1%) between weeks 20 and 24 of pregnancy. Two of them had received definitive therapy for Graves disease before pregnancy. Two neonates (7.1%) were at high risk of neonatal hyperthyroidism and were followed-up until two months, without hyperthyroidism signs or abnormal thyroid hormone levels. Compliance of protocol during pregnancy was 84.9% and 75.8% at birth.
Prevalence of Graves disease among pregnant women was 0.57%, with no cases of neonatal hyperthyroidism. Compliance of protocol was adequate during pregnancy (84.9%) and acceptable at birth (75.8%).
本前瞻性研究旨在描述患有活动性或既往 Graves 病的母亲所生新生儿的人口统计学和临床特征，并评估我们中心实施新方案后的依从性。
我们根据方案前瞻性地随访了 2019 年 8 月至 2021 年 9 月期间在西班牙一家三级医院出生的患有活动性或既往 Graves 病的母亲所生的新生儿。我们回顾了这些新生儿的母婴病史，并对有发生新生儿甲状腺功能亢进风险的新生儿进行了随访。
在 5808 例分娩中，有 33 例新生儿的母亲患有活动性或既往 Graves 病（0.57%）。6 名母亲（18.2%）在怀孕期间甲状腺刺激激素受体抗体水平呈阳性，5 名母亲（15.1%）在妊娠 20 至 24 周时呈阳性。其中 2 人在怀孕前接受过 Graves 病的确定性治疗。2 名新生儿（7.1%）有发生新生儿甲状腺功能亢进的高风险，并进行了 2 个月的随访，未出现甲状腺功能亢进的迹象或甲状腺激素水平异常。怀孕期间方案的依从性为 84.9%，出生时为 75.8%。
孕妇 Graves 病的患病率为 0.57%，无新生儿甲状腺功能亢进病例。怀孕期间方案的依从性较好（84.9%），出生时的依从性尚可（75.8%）。
