Mulder D W, Kurland L T
Adv Exp Med Biol. 1987;209:325-32. doi: 10.1007/978-1-4684-5302-7_49.
The etiology of motor neuron disease (MND) is unknown and treatment is limited to measures which sustain the patient. We review selected epidemiologic studies searching for a pattern in the clinical expression of MND which may reflect the operation of the underlying cause. Recognition of patterns of occurrence of MND might provide the basis for testable etiologic hypotheses for MND. In addition, recognition of the association of MND with diseases of known cause or the analogy of diseases of known cause with MND may provide further etiologic hypotheses.
运动神经元病（MND）的病因不明，治疗仅限于维持患者生命的措施。我们回顾了一些选定的流行病学研究，以寻找MND临床表型中的一种模式，这种模式可能反映潜在病因的作用机制。识别MND的发病模式可能为MND可检验的病因假说提供依据。此外，认识到MND与已知病因疾病的关联，或已知病因疾病与MND的相似性，可能提供更多的病因假说。
