School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-sen University, 510275 Guangzhou, Guangdong, China.
Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 510120 Guangzhou, Guangdong, China.
Nano Lett. 2022 May 25;22(10):4090-4096. doi: 10.1021/acs.nanolett.2c00796. Epub 2022 May 13.
Magnetic resonance (MR) imaging is very important for noninvasive lymphography. However, the present MR contrast agents still cannot supply strong enough tissue contrast and long observation window. To improve the performance of contrast agents, we introduce one-dimensional unimolecular nanoparticles with a confined and compact poly(acrylic acid) core as nanoparticulate chelates of gadolinium ions. Thus, obtained nanoparticulate contrast agents give relaxivity as high as 136.3 mM·s under 3.0 T. By injection at the footpad of mice, the contrast agents provide excellent contrast enhancement of lymphatic drainage and they may arrive at popliteal lymph nodes within 30 min and reside for more than 80 h. High performance of the present contrast agent is attributed to the confined and compact core of materials that increase hydration number, intershell water diffusion, and decrease rotational motion.
磁共振成像对于非侵入性淋巴造影非常重要。然而，目前的磁共振对比剂仍然不能提供足够强的组织对比度和长时间的观察窗口。为了提高对比剂的性能，我们引入了具有受限和紧凑的聚丙烯酸核的一维单分子纳米颗粒作为钆离子的纳米颗粒螯合物。因此，所得到的纳米颗粒对比剂在 3.0 T 下的弛豫率高达 136.3 mM·s。通过在小鼠的足垫注射，该对比剂可极好地增强淋巴管引流的对比度，并且可在 30 分钟内到达腘淋巴结，并持续 80 小时以上。目前对比剂的高性能归因于材料的受限和紧凑的核，这增加了水合数、壳层间水扩散并减少了旋转运动。
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