Department of Chemistry, Myongji University, Yongin, 17058, South Korea.
Centurion University of Technology and Management, Odisha, India.
Curr Top Med Chem. 2022;22(14):1152-1159. doi: 10.2174/1568026622666220512145646.
Heterocycles consisting of a nitrogen atom, Indazole, is a pungent, biological, heterocyclic, bicyclic compound possessing electron-rich portions. Indazole is composed of two nitrogen atoms put under the azoles family, further called isoindazolone. It is colorless solid nitrogen- containing heterocyclics with atomic formula-C7H6N2 are extraordinary scaffolds, still identified as isoindazole. Therefore, analogs of Indazole have experienced expert approaches in later times because of its special biological properties, such as anti-microbial, anti-inflammatory, anticancer, anti- HIV and antihypertensive actions. 1H-indazole and 2H-indazole are two toutomeric forms of Indazole. Sometimes, indazole produces three tautomeric forms that are 1H, 2H and 3H tautomers of indazole. 1H-indazole is reliable than 2H-indazole. We should note that a series of derivatives of indazole having 2H toutomers follow hybridization of cyclic systems and act as anti-inflammatory as well as anti-microbial compounds. It formed Indazole itself and derivatives of Indazole in natural products. A sequence of N-methyl-3-aryl inazoles has dominant against bacterial strains like xanthomon as campstris, Baillus cereus, Escherichia coli, Bacillus megaterium and a fungal strain candida albicans found by in-vitro anti-microbial study of indazole derivatives.
由氮原子组成的杂环化合物，吲唑，是一种刺鼻的、生物活性的、杂环、双环化合物，具有富电子部分。吲唑由两个氮原子组成，属于唑类家族，进一步称为异吲哚酮。它是无色固体含氮杂环化合物，原子式为 C7H6N2，是非常特殊的支架，仍然被鉴定为异吲哚酮。因此，吲唑的类似物因其特殊的生物学性质，如抗微生物、抗炎、抗癌、抗 HIV 和抗高血压作用，在后来受到了专家的关注。1H-吲唑和 2H-吲唑是吲唑的两种互变异构形式。有时，吲唑会产生三种互变异构形式，即吲唑的 1H、2H 和 3H 互变异构体。1H-吲唑比 2H-吲唑更可靠。我们应该注意的是，一系列具有 2H 互变异构体的吲唑衍生物遵循环状系统的杂化，并作为抗炎和抗微生物化合物。它在天然产物中形成吲唑本身和吲唑衍生物。一系列 N-甲基-3-芳基吲唑对黄单胞菌属 campstris、蜡状芽孢杆菌、大肠杆菌、巨大芽孢杆菌和白色念珠菌等细菌菌株具有优势，这是通过吲唑衍生物的体外抗微生物研究发现的。
