Department of Medicine, Kern Medical UCLA, Bakersfield, CA, USA.
Department of Medicine, Division of Infectious Diseases, Kern Medical UCLA, Bakersfield, CA, USA.
J Investig Med High Impact Case Rep. 2022 Jan-Dec;10:23247096221097526. doi: 10.1177/23247096221097526.
Patients with acquired immunodeficiency syndrome (AIDS) are at an increased susceptibility to pathogens and associated malignancies which can present with a unique constellation of symptoms. In this article, we describe a case of Castleman disease in a patient with AIDS, nonadherent with antiretroviral therapy (ART), who presented with fevers, constant abdominal pain, nausea, and vomiting. After an extensive work up, a lymph node biopsy confirmed a diagnosis of human herpesvirus-8 (HHV-8)-associated multicentric Castleman disease. Patients presenting with AIDS and fever have broad differential diagnoses; therefore, reaching a diagnosis as rare as Castleman disease can be challenging. HHV-8 has a propensity to CD20 positive B cells, which allows rituximab to be an effect treatment.
获得性免疫缺陷综合征（AIDS）患者对病原体和相关恶性肿瘤的易感性增加，这些病原体和相关恶性肿瘤可能表现出独特的症状组合。在本文中，我们描述了一例 AIDS 患者、不遵医嘱接受抗逆转录病毒治疗（ART）的 Castleman 病病例，该患者表现为发热、持续腹痛、恶心和呕吐。经过广泛的检查，淋巴结活检证实了人类疱疹病毒 8 型（HHV-8）相关的多中心 Castleman 病的诊断。患有 AIDS 并发热的患者有广泛的鉴别诊断；因此，诊断像 Castleman 病这样罕见的疾病可能具有挑战性。HHV-8 倾向于 CD20 阳性 B 细胞，这使得利妥昔单抗成为一种有效的治疗方法。
