Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, PR China.
Wuchang University of Technology, Wuhan, Hubei, PR China.
Environ Pollut. 2022 Aug 1;306:119439. doi: 10.1016/j.envpol.2022.119439. Epub 2022 May 9.
Exposure to metals has been linked with the risk of hypertensive disorders of pregnancy (HDP), but little is known about the potential effects of exposure to metal mixtures. Thus, our study aimed to investigated the impact of a complex mixture of metals on HDP, especially the interactions among metal mixtures. We did a population-based nested case-control study from October 2013 to October 2016 in Wuhan, China, including 146 HDP cases and 292 controls. Plasma concentrations of Aluminum (Al), Barium (Ba), Cobalt (Co), Copper (Cu), Lead (Pb), Mercury (Hg), Molybdenum (Mo), Nickel (Ni), Selenium (Se), Strontium (Sr), Thallium (Tl), and Vanadium (V) were measured and collected between 10 and 16 gestational weeks. We employed quantile g-computation, conditional logistic regression models, and Bayesian Kernel Machine Regression (BKMR) to assess the association of individual metals and metal mixtures with HDP risk. In the quantile g-computation, the OR for a joint tertile increase in plasma concentrations was 3.67 (95% CI: 1.70, 7.91). Hg contributed the largest positive weights and followed by Al, Ni, and V. In conditional logistic regression models, concentrations of Hg, Al, Ni, and V were significantly associated with the risk of HDP (p-FDR < 0.05). Compared to the lowest tertiles, the ORs (95% CI) for the highest tertiles of these four metals were 2.67 (1.44, 4.95), 3.09 (1.70, 5.64), 5.31 (2.68, 10.53), and 4.52 (2.26, 9.01), respectively. In the BKMR analysis, we observed a linear positive association between Hg, Al, V, and HDP, and a nonlinear relationship between Ni and HDP. A potential interaction between Al and V was also identified. We found that exposure to metal mixtures in early pregnancy, both individually and as a mixture, was associated with the risk of HDP. Potential interaction effects of Al and V on the risk of HDP may exist.
金属暴露与妊娠高血压疾病（HDP）的风险有关，但对于金属混合物暴露的潜在影响知之甚少。因此，我们的研究旨在探讨复杂金属混合物对 HDP 的影响，特别是金属混合物之间的相互作用。我们在中国武汉进行了一项基于人群的嵌套病例对照研究，时间为 2013 年 10 月至 2016 年 10 月，包括 146 例 HDP 病例和 292 例对照。在妊娠 10-16 周时测量并收集了血浆中铝（Al）、钡（Ba）、钴（Co）、铜（Cu）、铅（Pb）、汞（Hg）、钼（Mo）、镍（Ni）、硒（Se）、锶（Sr）、铊（Tl）和钒（V）的浓度。我们采用分位数 g 计算、条件 logistic 回归模型和贝叶斯核机器回归（BKMR）来评估个体金属和金属混合物与 HDP 风险的关联。在分位数 g 计算中，血浆浓度联合三分位增加的比值比（OR）为 3.67（95%CI：1.70，7.91）。Hg 贡献了最大的正权重，其次是 Al、Ni 和 V。在条件 logistic 回归模型中，Hg、Al、Ni 和 V 的浓度与 HDP 风险显著相关（p-FDR < 0.05）。与最低三分位相比，这四种金属最高三分位的 OR（95%CI）分别为 2.67（1.44，4.95）、3.09（1.70，5.64）、5.31（2.68，10.53）和 4.52（2.26，9.01）。在 BKMR 分析中，我们观察到 Hg、Al、V 和 HDP 之间呈线性正相关，Ni 和 HDP 之间呈非线性关系。还发现 Al 和 V 之间存在潜在的相互作用。我们发现，妊娠早期金属混合物的暴露，无论是单独暴露还是混合暴露，都与 HDP 的风险有关。Al 和 V 对 HDP 风险的潜在交互作用可能存在。
