Small Animal Referral Clinic Papadopoulos and Eßrich, Berlin, Germany.
Institute of Veterinary Epidemiology and Biostatistics, Department of Veterinary Medicine, Free University Berlin, Germany.
Vet Anaesth Analg. 2022 Jul;49(4):407-416. doi: 10.1016/j.vaa.2021.09.021. Epub 2022 Mar 17.
To determine the effect of blocking the obturator nerve in addition to performing femoral nerve and sciatic nerve blocks on intraoperative nociception in dogs undergoing unilateral tibial plateau levelling osteotomy (TPLO) surgery.
Prospective, blinded, randomized, placebo-controlled, clinical comparison.
A total of 88 client-owned dogs undergoing unilateral TPLO surgery (100 procedures).
Dogs were randomly assigned to either group FSO (femoral, sciatic and obturator nerve blocks) [n = 50; ropivacaine 0.75% (0.75 mg kg)] or group FSP (femoral, sciatic and placebo) [n = 50; ropivacaine 0.75% (0.75 mg kg) femoral and sciatic nerve blocks plus saline solution 0.9% (0.1 mL kg) as a placebo injection around the obturator nerve]. The anaesthetic protocol was standardized. Data collection included intraoperative cardiopulmonary variables and opioid consumption. Rescue analgesia consisted of an intravenous bolus of fentanyl (2 μg kg) and was administered when a change in cardiopulmonary variables (20% increase in mean arterial pressure or heart rate) was attributed to a sympathetic stimulus. Data were analysed using generalized linear mixed models, cross tables and multivariable binary logistic regression. Results were expressed as adjusted odds ratios with 95% confidence intervals and Wald p values (α = 0.05).
There were no clinically relevant differences between groups in intraoperative cardiopulmonary variables and need for rescue analgesia. The requirement for rescue analgesia was significantly higher in dogs with a body weight >34 kg.
Anaesthesia of the obturator nerve in addition to the femoral and sciatic nerves was not associated with clinically significant differences in cardiopulmonary variables or a reduced need for rescue analgesia. Therefore, the clinical benefit of an additional obturator nerve block for intraoperative antinociception in dogs undergoing unilateral TPLO surgery using the described anaesthetic regimen is low.
在接受单侧胫骨平台抬高截骨术(TPLO)的犬中,除了进行股神经和坐骨神经阻滞外,阻断闭孔神经对术中痛觉的影响。
前瞻性、盲法、随机、安慰剂对照、临床比较。
共 88 只接受单侧 TPLO 手术的犬(100 例)。
犬随机分为 FSO 组(股神经、坐骨神经和闭孔神经阻滞)[n=50;罗哌卡因 0.75%(0.75mg/kg)]或 FSP 组(股神经、坐骨神经和安慰剂)[n=50;罗哌卡因 0.75%(0.75mg/kg)股神经和坐骨神经阻滞加生理盐水 0.9%(0.1mL/kg)作为闭孔神经周围的安慰剂注射]。麻醉方案标准化。数据收集包括术中心肺变量和阿片类药物的消耗。补救性镇痛包括静脉注射芬太尼(2μg/kg),当心肺变量发生变化(平均动脉压或心率增加 20%)归因于交感神经刺激时给予。使用广义线性混合模型、交叉表和多变量二项逻辑回归分析数据。结果表示为调整后的优势比及其 95%置信区间和 Wald p 值(α=0.05)。
两组在术中心肺变量和需要补救性镇痛方面无临床相关差异。体重>34kg 的犬需要补救性镇痛的可能性明显更高。
除股神经和坐骨神经外,对闭孔神经进行麻醉并不会导致心肺变量出现临床显著差异或减少对补救性镇痛的需求。因此,在描述的麻醉方案中,对于接受单侧 TPLO 手术的犬,除了股神经和坐骨神经阻滞外,额外进行闭孔神经阻滞以获得术中镇痛的临床获益较低。