Provincial Clinical College, Fujian Medical University, Fuzhou, China.
Department of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, China.
Lab Med. 2022 Sep 1;53(5):488-494. doi: 10.1093/labmed/lmac027.
To evaluate the prognostic values of serum PIVKA-II (prothrombin induced by vitamin K absence-II) and α-fetoprotein (AFP) and the combination of these analytes for identifying hepatocellular carcinoma (HCC), and to analyze the correlation between biomarkers and clinicopathological features of HCC.
The levels of PIVKA-II and AFP in 331 case individuals were determined by upconverting phosphor technology-based immune lateral flow (UPT-LF) assay. We used the ROC curve to determine the diagnostic value; the relationships between the biomarkers and clinicopathological features of HCC also were analyzed.
AFP and PIVKA-II have good diagnostic performance in the diagnosis of HCC; the best AUC was 0.76, 0.74. High levels of PIVKA-II were more advantageous than AFP in predicting tumor size, portal-vein embolism, and vascular invasion (all P <.05).
Levels of PIVKA-II and AFP showed good diagnostic value for HCC, but the level of PIVKA-II was more closely related to the clinicopathological features of HCC.
评估血清异常凝血酶原（维生素 K 缺乏诱导的蛋白质Ⅱ）和甲胎蛋白（AFP）的预后价值，并分析这些分析物联合用于识别肝细胞癌（HCC）的价值，同时分析生物标志物与 HCC 临床病理特征之间的相关性。
采用基于上转换磷光技术的免疫侧向流动（UPT-LF）检测法测定 331 例个体的 PIVKA-II 和 AFP 水平。我们使用 ROC 曲线来确定诊断价值；还分析了生物标志物与 HCC 临床病理特征之间的关系。
AFP 和 PIVKA-II 在 HCC 诊断中具有良好的诊断性能；最佳 AUC 分别为 0.76、0.74。高水平的 PIVKA-II 在预测肿瘤大小、门静脉癌栓和血管侵犯方面优于 AFP（均 P<.05）。
PIVKA-II 和 AFP 水平对 HCC 具有良好的诊断价值，但 PIVKA-II 水平与 HCC 的临床病理特征更密切相关。
