FENNSI Group, Hospital Nacional de Parapléjicos, SESCAM, Finca La Peraleda s/n, 45071, Toledo, Spain.
Universidad de Castilla la Mancha, Talavera de la Reina, Toledo, Spain.
Sci Rep. 2022 May 12;12(1):7834. doi: 10.1038/s41598-022-11859-5.
Focal application of transcranial static magnetic field stimulation (tSMS) over the human motor cortex induces local changes in cortical excitability. Whether tSMS can also induce distant network effects, and how these local and distant effects may vary over time, is currently unknown. In this study, we applied 10 min tSMS over the left motor cortex of healthy subjects using a real/sham parallel design. To measure tSMS effects at the sensori-motor network level, we used resting-state fMRI. Real tSMS, but not sham, reduced functional connectivity within the stimulated sensori-motor network. This effect of tSMS showed time-dependency, returning to sham levels after the first 5 min of fMRI scanning. With 10 min real tSMS over the motor cortex we did not observe effects in other functional networks examined (default mode and visual system networks). In conclusion, 10 min of tSMS over a location within the sensori-motor network reduces functional connectivity within the same functional network.
经颅静磁场刺激(tSMS)在人类运动皮层的局部应用可引起皮质兴奋性的局部变化。tSMS 是否也能引起远距离的网络效应,以及这些局部和远距离的效应如何随时间变化,目前尚不清楚。在这项研究中,我们使用真实/假并行设计,对健康受试者的左运动皮层进行了 10 分钟的 tSMS 治疗。为了在感觉运动网络水平上测量 tSMS 的效果,我们使用了静息态 fMRI。真正的 tSMS 而不是假的 tSMS 降低了刺激感觉运动网络内的功能连接。tSMS 的这种作用具有时间依赖性,在 fMRI 扫描的前 5 分钟后恢复到假水平。在对运动皮层进行 10 分钟的真实 tSMS 治疗后,我们没有观察到在其他检查的功能网络(默认模式和视觉系统网络)中出现效果。总之,在感觉运动网络内的一个位置进行 10 分钟的 tSMS 治疗可降低同一功能网络内的功能连接。