Neuroscience Program, Colorado College, Colorado Springs, Colorado.
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Eur J Neurosci. 2019 Jan;49(2):250-262. doi: 10.1111/ejn.14232. Epub 2018 Dec 3.
Transcranial static magnetic field stimulation (tSMS) is a novel non-invasive brain stimulation technique that has been shown to locally increase alpha power in the parietal and occipital cortex. We investigated if tSMS locally increased alpha power in the left or right prefrontal cortex, as the balance of left/right prefrontal alpha power (frontal alpha asymmetry) has been linked to emotional processing and mood disorders. Therefore, altering frontal alpha asymmetry with tSMS may serve as a novel treatment to psychiatric diseases. We performed a crossover, double-blind, sham-controlled pilot study to assess the effects of prefrontal tSMS on neural oscillations. Twenty-four right-handed healthy participants were recruited and received left dorsolateral prefrontal cortex (DLPFC) tSMS, right DLPFC tSMS, and sham tSMS in a randomized order. Electroencephalography data were collected before (2 min eyes-closed, 2 min eyes-open), during (10 min eyes-open), and after (2 min eyes-open) stimulation. In contrast with our hypothesis, neither left nor right tSMS locally increased frontal alpha power. However, alpha power increased in occipital cortex during left DLPFC tSMS. Right DLPFC tSMS increased post-stimulation fronto-parietal theta power, indicating possible relevance to memory and cognition. Left and right DLPFC tSMS increased post-stimulation left hemisphere beta power, indicating possible changes to motor behavior. Left DLPFC tSMS also increased post-stimulation right frontal beta power, demonstrating complex network effects that may be relevant to aggressive behavior. We concluded that DLPFC tSMS modulated the network oscillations in regions distant from the location of stimulation and that tSMS has region specific effects on neural oscillations.
经颅静磁场刺激（tSMS）是一种新颖的非侵入性脑刺激技术，已被证明可局部增加顶叶和枕叶皮质的α 功率。我们研究了 tSMS 是否会局部增加左或右前额叶皮质的α 功率，因为左/右前额叶α 功率的平衡（前额叶α 不对称）与情绪处理和情绪障碍有关。因此，用 tSMS 改变前额叶α 不对称可能成为治疗精神疾病的新方法。我们进行了一项交叉、双盲、假刺激对照的初步研究，以评估前额叶 tSMS 对神经振荡的影响。招募了 24 名右利手健康参与者，并以随机顺序接受左背外侧前额叶皮质（DLPFC）tSMS、右 DLPFC tSMS 和假 tSMS。在刺激前（闭眼 2 分钟，睁眼 2 分钟）、刺激期间（睁眼 10 分钟）和刺激后（睁眼 2 分钟）收集脑电图数据。与我们的假设相反，左或右 tSMS 均未局部增加前额叶 α 功率。然而，在左 DLPFC tSMS 期间，枕叶皮质的α 功率增加。右 DLPFC tSMS 增加了刺激后的额顶叶θ 功率，表明可能与记忆和认知有关。左、右 DLPFC tSMS 增加了刺激后的左半球β 功率，表明可能改变了运动行为。左 DLPFC tSMS 还增加了刺激后的右额β 功率，显示出可能与攻击性行为有关的复杂网络效应。我们得出结论，DLPFC tSMS 调节了远离刺激部位的区域的网络振荡，并且 tSMS 对神经振荡具有区域特异性影响。
