Arnaud D, Blache J L, Courtinat C, Bouffier C, Dubouloz F
Ann Fr Anesth Reanim. 1987;6(1):42-4. doi: 10.1016/s0750-7658(87)80009-6.
A case is reported of rapidly resolving pulmonary oedema following post-extubation laryngospasm in a 23 year-old healthy man who underwent emergency resection of a rectal polyp. The laryngospasm occurred immediately after extubation and resolved after administration of curare. The patient was reintubated and auscultation disclosed bilateral coarse and moist rales. Chest X-ray displayed a right pulmonary opacity. Because of the deteriorating respiratory status, mechanical ventilation was used with positive end-expiratory pressure for 18 h. Chest examination, chest X-ray and arterial blood gas levels improved steadily and the patient was discharged 24 h later. Pulmonary oedema associated with upper airway obstruction seems to be related to hypoxic pulmonary vasoconstriction and the largely subatmospheric transpulmonary pressure gradients generated while trying to breathe against a closed glottis. In addition, this increased negative intra-alveolar pressure was responsible for significant changes in cardiovascular function: right ventricular blood volume, right ventricular ejection fraction and left ventricular after-load increased, while left ventricular ejection fraction decreased. These changes favoured a rise in left atrial and pulmonary blood volumes, with transudation of fluid from the capillaries into the alveoli. Because of the severe consequences of respiratory failure, any patient who suffers acute upper airway obstruction should be observed in the recovery room for at least 3 h in order not to miss this rarely developing, but fortunately rapidly reversible, syndrome.
报告了一例23岁健康男性在直肠息肉急诊切除术后拔管后发生喉痉挛,随后迅速缓解的肺水肿病例。喉痉挛在拔管后立即发生,在给予箭毒后缓解。患者重新插管,听诊发现双侧有粗湿啰音。胸部X线显示右肺有片状模糊影。由于呼吸状况恶化,使用机械通气并加用呼气末正压通气18小时。胸部检查、胸部X线和动脉血气水平稳步改善,患者于24小时后出院。与上呼吸道梗阻相关的肺水肿似乎与低氧性肺血管收缩以及试图对抗关闭的声门呼吸时产生的大量低于大气压的跨肺压力梯度有关。此外,肺泡内负压增加导致心血管功能发生显著变化:右心室血容量、右心室射血分数和左心室后负荷增加,而左心室射血分数降低。这些变化促使左心房和肺血容量增加,液体从毛细血管渗入肺泡。由于呼吸衰竭的严重后果,任何遭受急性上呼吸道梗阻的患者都应在恢复室观察至少3小时,以免漏诊这种罕见但幸运的是可迅速逆转的综合征。